Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis Q.-A. Dar, R.D.

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Presentation transcript:

Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis Q.-A. Dar, R.D. Maynard, Z. Liu, E.M. Schott, S. Catheline, R.A. Mooney, M.J. Hilton, J. Prawitt, M.J. Zuscik Osteoarthritis and Cartilage Volume 24, Pages S532-S533 (April 2016) DOI: 10.1016/j.joca.2016.01.976 Copyright © 2016 Terms and Conditions

Fig. 1. Safranin O/Fast Green staining of knee joints 12 weeks after MLI reveals enhanced pericellular proteoglycan content and thicker articular cartilage on the tibial plateau in LD and HD Peptan-treated groups (A). Histomorphometry revealed significant positive effects of Peptan on tibial uncalcified cartilage area (B), total cell (chondrocyte) counts in the tibial uncalcified cartilage (C) as well as an increased percentage (D) of Safranin O+ cells. x,* = p < 0.05, xxx,*** = p < 0.001, 2 way ANOVA & Bonferroni-Dunn multiple comparison, N=6; x or xxx denotes differences between sham and MLI within each group. Osteoarthritis and Cartilage 2016 24, S532-S533DOI: (10.1016/j.joca.2016.01.976) Copyright © 2016 Terms and Conditions