Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation

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Presentation transcript:

Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation Akgun Oral, M.D., Fehmi Odabasoglu, Ph.D., Zekai Halici, M.D., Osman Nuri Keles, M.Sc., Bunyami Unal, M.D., Ph.D., A. Kagan Coskun, M.D., Cenk Kilic, M.D., İlhami Surer, M.D., A.B. Salman, M.D. Fertility and Sterility Volume 95, Issue 4, Pages 1360-1366 (March 2011) DOI: 10.1016/j.fertnstert.2010.08.017 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Histologic micrographs of control group: (A) Ovarian tissues in control group showing ovarian cortex (C), ovarian follicles (Of), corpus luteum (Cl) and stroma (S), and medulla (M). (B) The cells of corpus luteum (Cl), stroma (S), and tunica albuginea (Ta). Histologic micrographs of montelukast group: (C) Cortex (C) and medulla (M). (D) The cells of stroma (S), and primary (Pf) and secondary follicles (Sf). (E) Schematic drawing of applying vascular clips below the ovaries in rats (ischemia). (F) Schematic drawing of reperfusion. Fertility and Sterility 2011 95, 1360-1366DOI: (10.1016/j.fertnstert.2010.08.017) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Histologic micrographs of the ischemia group: (A) Widespread hemorrhage (Wh). (B) Higher magnification revealing necrotic granulosa (Gc) and stromal cells with hemorrhage (H). Tunica albuginea (Ta). Histologic micrograph of ischemia plus 10 mg montelukast group: (C) Moderate hemorrhage and vascular congestion. (D) Hemorrhage (H) corona radiata (Cr). Histologic micrograph of ischemia plus 20 mg montelukast group: (E) Corpus luteum (Cl), corpus hemorrhagicum (Ch), and ovarian follicles (Of). Moderate hemorrhage (Mh) with vascular congestion. (F) Capillary congestions (Ca). Granulosa luteal (Glc) and stromal cells (Sc). Fertility and Sterility 2011 95, 1360-1366DOI: (10.1016/j.fertnstert.2010.08.017) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Histologic micrographs of ischemia-reperfusion group: (A) (B) Ovarian cortex with edema (E); neutrophils (black arrows) were also abundant in blood vessels (V), and the cortex also had apoptotic cells (white arrows). Histologic micrographs of ischemia-reperfusion plus 10 mg montelukast group: (C) Ovarian cortex (C), ovarian follicles (Of), (D) stroma, (Sc) and tunica albuginea (Ta). Histologic micrographs of ischemia-reperfusion plus 20 mg montelukast group: (E) Hemorrhage observed only around ovarian follicles (black arrows). (F) Tunica albuginea (Ta) and granulosa luteal cells (Glc) observed with normal morphologic features. Fertility and Sterility 2011 95, 1360-1366DOI: (10.1016/j.fertnstert.2010.08.017) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions