The Phosphatase PP2A Links Glutamine to the Tumor Suppressor p53

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The Phosphatase PP2A Links Glutamine to the Tumor Suppressor p53 Dana Gwinn, E. Alejandro Sweet-Cordero Molecular Cell Volume 50, Issue 2, Pages 157-158 (April 2013) DOI: 10.1016/j.molcel.2013.04.010 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 When Glutamine Is Present, It Is Used to Fuel the TCA Cycle and Also Contributes to ROS Homeostasis, among Other Roles Under these conditions, EDD is phosphorylated and does not exert negative regulation of p53. However, when glutamine is withdrawn, TCA cycle flux decreases and ROS accumulates. Under these conditions, the PP2A subunit, B55a, is upregulated, leading to dephosphorylation of EDD, allowing for increased p53 activity, including expression of the cell-cycle inhibitor, p21, as well as glutaminase 2 (Gls2). Molecular Cell 2013 50, 157-158DOI: (10.1016/j.molcel.2013.04.010) Copyright © 2013 Elsevier Inc. Terms and Conditions