Molecular alterations in colitis-associated colorectal neoplasia: Study from a low prevalence area using magnifying chromo colonoscopy  Bhadravathi Marigowda.

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Molecular alterations in colitis-associated colorectal neoplasia: Study from a low prevalence area using magnifying chromo colonoscopy  Bhadravathi Marigowda Shivakumar, Balasubramanian Lakshman Kumar, Ganesh Bhat, Deepak Suvarna, Lakshmi Rao, C. Ganesh Pai, Kapaettu Satyamoorthy  Journal of Crohn's and Colitis  Volume 6, Issue 6, Pages 647-654 (July 2012) DOI: 10.1016/j.crohns.2011.11.013 Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 1 Microsatellite Instability (MSI) analysis for Bethesda panel of markers: A) multiplex PCR products of normal (Nr) and abnormal (Ab) on agarose gel along with marker (M); B) Matching normal (Nr) and abnormal sample (Ab) analyzed through the capillary electrophoresis and fragment analysis showing the presence of instability in the abnormal sample. Journal of Crohn's and Colitis 2012 6, 647-654DOI: (10.1016/j.crohns.2011.11.013) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 2 Clinicopathological and molecular features of one of the high grade samples: A) Chromo colonoscopic image showing raised and abnormal pit pattern; B) H&E of the same showing high grade dysplasia; C) Electropherogram showing mutation (indicated by arrows) in KRAS gene at codon 13 (G>GA;G13D) and d) p53 gene mutation at codon 196 (C>CT; R196X). Journal of Crohn's and Colitis 2012 6, 647-654DOI: (10.1016/j.crohns.2011.11.013) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

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