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Deep Brain Stimulation (DBS) Prof. Philip Cowen Professor of Psychopharmacology Department of Psychiatry University of Oxford, UK
Deep Brain Stimulation (DBS) Tracy DK, David AS. Clinical neuromodulation in psychiatry: the state of the art or an art in a state?. BJPsych Advances. 2015 Nov 1;21(6):396-404.
Deep Brain Stimulation (DBS) Treatment of Parkinson’s disease Implantation of electrodes in the subthalamic nucleus Mood improvement Studies in depression Tracy DK, David AS. Clinical neuromodulation in psychiatry: the state of the art or an art in a state?. BJPsych Advances. 2015 Nov 1;21(6):396-404.
Deep Brain Stimulation (DBS) Treatment of Parkinson’s disease Implantation of electrodes in the subthalamic nucleus Mood improvement Studies in depression Tracy DK, David AS. Clinical neuromodulation in psychiatry: the state of the art or an art in a state?. BJPsych Advances. 2015 Nov 1;21(6):396-404.
Deep Brain Stimulation (DBS) Treatment of Parkinson’s disease Implantation of electrodes in the subthalamic nucleus Mood improvement Studies in depression
Deep Brain Stimulation (DBS) Neurosurgical procedure Stereotactic surgery Depression: experimental treatment
Deep Brain Stimulation (DBS) Neurosurgical procedure Stereotactic surgery Depression: experimental treatment
Deep Brain Stimulation (DBS) Target regions Subgenual cingulate cortex Ventral striatum Meta-analysis of four observational studies 12-month remission rate of 26 percent highly treatment refractory patients no benefit shown in sham controlled studies Effectiveness remains to be shown
Deep Brain Stimulation (DBS) Target regions Subgenual cingulate cortex Ventral striatum Meta-analysis of four observational studies 12-month remission rate of 26 percent highly treatment refractory patients no benefit shown in sham controlled studies Effectiveness remains to be shown
Deep Brain Stimulation (DBS) Target regions Subgenual cingulate cortex Ventral striatum Meta-analysis of four observational studies 12-month remission rate: 26 % Highly treatment refractory patients no benefit shown in sham controlled studies Effectiveness remains to be shown Berlim MT, McGirr A, Van den Eynde F, et al (2014) Effectiveness and acceptability of deep brain stimulation (DBS) of the subgenual cingulate cortex for treatment resistant depression: a systematic review and exploratory meta-analysis. Journal of Affective Disorders, 159: 31–8
Deep Brain Stimulation (DBS) Target regions Subgenual cingulate cortex Ventral striatum Meta-analysis of four observational studies 12-month remission rate:26% No benefit shown in sham controlled studies Effectiveness remains to be shown Berlim MT, McGirr A, Van den Eynde F, et al (2014) Effectiveness and acceptability of deep brain stimulation (DBS) of the subgenual cingulate cortex for treatment resistant depression: a systematic review and exploratory meta-analysis. Journal of Affective Disorders, 159: 31–8
Key Points DBS Requires brain surgery Its efficacy hasn’t yet been shown in controlled studies
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