Epigenetic Mechanisms of Longevity and Aging

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Epigenetic Mechanisms of Longevity and Aging Payel Sen, Parisha P. Shah, Raffaella Nativio, Shelley L. Berger Cell Volume 166, Issue 4, Pages 822-839 (August 2016) DOI: 10.1016/j.cell.2016.07.050 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The Epigenetic Hallmarks of Senescence and Aging (A–J) Senescence and aging are characterized by (A) loss of histones, (B) imbalance of activating and repressive modifications, (C) transcriptional changes, (D) losses and gains in heterochromatin, (E) breakdown of nuclear lamina, (F) global hypomethylation and focal hypermethylation, and (G) chromatin remodeling. These changes are heavily dictated by (H) environmental stimuli and (I) nutrient availability that in turn (J) alter intracellular metabolite concentrations. Cell 2016 166, 822-839DOI: (10.1016/j.cell.2016.07.050) Copyright © 2016 Elsevier Inc. Terms and Conditions