C1ORF106 contributes to intestinal epithelial barrier function.

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C1ORF106 contributes to intestinal epithelial barrier function. C1ORF106 contributes to intestinal epithelial barrier function. (A and B) Colon weight-to-length ratio. (C) Representative image of cecum and colon of WT and KO mice after TNF treatment. (D) FITC-dextran levels in serum 4 h postgavage in c1orf106 WT and KO mice treated with or without TNF-α. (E) H&E (right panel) and caspase 3 (left panel) staining of ileal tissue of WT and KO mice after LPS treatment. Apoptotic cell bodies are indicated with white asterisks. Scale bars, 200 μm. *p < 0.05, **p < 0.01. Paolo Manzanillo et al. ImmunoHorizons 2018;2:164-171 Copyright © 2018 The Authors