A. K. Suokas, D. A. Walsh, D. F. McWilliams, L. Condon, B. Moreton, V

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Quantitative sensory testing in painful osteoarthritis: a systematic review and meta- analysis A.K. Suokas, D.A. Walsh, D.F. McWilliams, L. Condon, B. Moreton, V. Wylde, L. Arendt-Nielsen, W. Zhang Osteoarthritis and Cartilage Volume 20, Issue 10, Pages 1075-1085 (October 2012) DOI: 10.1016/j.joca.2012.06.009 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow diagram of study selection. Osteoarthritis and Cartilage 2012 20, 1075-1085DOI: (10.1016/j.joca.2012.06.009) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Forest plot showing the SMD (95%CIs) for PPT between people with OA and healthy controls, grouped by QST site in relation to the affected joint (affected joint, distal, remote, other). L1–L5=lumbar vertebrae, S1–S2=sacral vertebrae, MCP=metacarpophalangeal. Other=average threshold measured from both sides of the body. Negative SMD means lower pain threshold in OA compared with control. Osteoarthritis and Cartilage 2012 20, 1075-1085DOI: (10.1016/j.joca.2012.06.009) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Forest plot showing the SMD (95%CIs) for PPT between people with OA and healthy controls. The anatomical test site with the smallest SMD was selected from each study. Test for heterogeneity: Cochran Q=6.34, P=0.39, I2 (inconsistency)=5% (95%CI=0–61%). Negative SMD means lower pain threshold in OA compared with control. Osteoarthritis and Cartilage 2012 20, 1075-1085DOI: (10.1016/j.joca.2012.06.009) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Funnel plot for PPT studies (n=7) comparing people with OA and healthy controls. The anatomical test site with the smallest SMD was selected from each study and categorised into affected joint, distal site, remote site, or other. Test for publication bias: Egger’s test=−0.70 (95%CI=−4.88 to 3.48), P=0.69. Osteoarthritis and Cartilage 2012 20, 1075-1085DOI: (10.1016/j.joca.2012.06.009) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Forest plot showing the pooled SMD (95%CIs, n=number of studies, pts=number of study participants) for PPT between people with OA and healthy controls. The smallest SMD for the affected joint, distal site, and the remote site were selected from each study and pooled within these three categories. Negative SMD means lower pain threshold in OA compared with control. Osteoarthritis and Cartilage 2012 20, 1075-1085DOI: (10.1016/j.joca.2012.06.009) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Sample size and power calculation based on the minimum SMD. Osteoarthritis and Cartilage 2012 20, 1075-1085DOI: (10.1016/j.joca.2012.06.009) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions