Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

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Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

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Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A. Morgan, MD, Faisal H. Cheema, MD, Mehmet C. Oz, MD The Annals of Thoracic Surgery Volume 80, Issue 6, Pages 2242-2249 (December 2005) DOI: 10.1016/j.athoracsur.2005.05.016 Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Mean neurologic scores of animals demonstrated a significant difference (p < 0.001) between control and treatment groups at each time point (8 hours, 16 hours, and 24 hours). The Annals of Thoracic Surgery 2005 80, 2242-2249DOI: (10.1016/j.athoracsur.2005.05.016) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Hematoxylin and eosin staining (magnification, ×100). (A) Group A, resveratrol-treated rabbits. (B) Group B, nontreated rabbits. The Annals of Thoracic Surgery 2005 80, 2242-2249DOI: (10.1016/j.athoracsur.2005.05.016) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Total number of motor neurons in the gray matter. The Annals of Thoracic Surgery 2005 80, 2242-2249DOI: (10.1016/j.athoracsur.2005.05.016) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Effect of resveratrol pretreatment on spinal cord neutrophil accumulation in rabbits 24 hours after surgery. Myeloperoxidase (MPO) activity (ΔAbs 460 nm/min) was determined to quantify neutrophil deposition in the ischemic reperfused spinal cord tissue. The Annals of Thoracic Surgery 2005 80, 2242-2249DOI: (10.1016/j.athoracsur.2005.05.016) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Malondialdehyde (MDA) levels of lumbar spinal cord segments 24 hours after reperfusion. The Annals of Thoracic Surgery 2005 80, 2242-2249DOI: (10.1016/j.athoracsur.2005.05.016) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions