Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension Edward P Chen, MD, Shahab A Akhter, MD, Hartmuth.

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Presentation transcript:

Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension Edward P Chen, MD, Shahab A Akhter, MD, Hartmuth B Bittner, MD, PhD, Walter J Koch, PhD, R.Duane Davis, MD, Peter Van Trigt, MD The Annals of Thoracic Surgery Volume 67, Issue 4, Pages 1053-1058 (April 1999) DOI: 10.1016/S0003-4975(99)00142-3

Fig 1 Differences in right and left ventricular β-adrenergic receptor (β-AR) density between the two groups in monocrotaline pyrrole (MCTP)–induced chronic pulmonary hypertension. Eight weeks after injection, significant increases were observed in β-AR density in the right ventricle (RV) of the MCTP group compared with controls (CTL); no significant differences were observed in β-AR density in the left ventricle (LV). (∗ = p < 0.005 versus CTL.) The Annals of Thoracic Surgery 1999 67, 1053-1058DOI: (10.1016/S0003-4975(99)00142-3)

Fig 2 Differences in right and left ventricular basal adenylate cyclase activity (%NaF [sodium fluoride]) between the two groups in monocrotaline pyrrole (MCTP)–induced chronic pulmonary hypertension. Eight weeks after injection, there were no significant differences in this activity between groups in either the right ventricle (RV) or the left ventricle (LV). (CTL = controls.) The Annals of Thoracic Surgery 1999 67, 1053-1058DOI: (10.1016/S0003-4975(99)00142-3)

Fig 3 Differences in right and left ventricular isoproterenol-stimulated adenylate cyclase activity (%NaF [sodium fluoride]) between the two groups in monocrotaline pyrrole (MCTP)–induced chronic pulmonary hypertension. Eight weeks after injection, significant increases were observed in isoproterenol-stimulated activity of the right ventricle (RV) in the MCTP group compared with controls (CTL); no significant differences were observed in the left ventricle (LV). (∗ = p < 0.05 versus CTL.) The Annals of Thoracic Surgery 1999 67, 1053-1058DOI: (10.1016/S0003-4975(99)00142-3)

Fig 4 Differences in right and left ventricular α1-adrenergic receptor (α-AR) density between the two groups in monocrotaline pyrrole (MCTP)–induced chronic pulmonary hypertension. Eight weeks after injection, significant increases were observed in α1-AR density in the right ventricle (RV) of the MCTP group compared with controls (CTL); no significant differences were observed in α1-AR density in the left ventricle (LV). (∗ = p < 0.005 versus CTL.) The Annals of Thoracic Surgery 1999 67, 1053-1058DOI: (10.1016/S0003-4975(99)00142-3)