PTEN Enters the Nuclear Age

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Presentation transcript:

PTEN Enters the Nuclear Age Suzanne J. Baker Cell Volume 128, Issue 1, Pages 25-28 (January 2007) DOI: 10.1016/j.cell.2006.12.023 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Nuclear and Cytoplasmic Function and Regulation of PTEN In the cytoplasm, PI3K is activated downstream of receptor tyrosine kinases and G protein-coupled receptors to convert PIP2 to PIP3, leading to AKT activation and enhanced growth, proliferation, and survival. PTEN phosphatase antagonizes PI3K by converting PIP3 to PIP2. Wang et al. (2007) show that NEDD4-1 polyubiquitinates PTEN, promoting its degradation in the cytoplasm, while Trotman et al. (2007) show that monoubiquitination increases nuclear localization of PTEN. Nuclear PTEN could function as a lipid phosphatase as it does in the cytoplasm but may also be involved in maintaining genomic integrity as shown by Shen et al. (2007). Cell 2007 128, 25-28DOI: (10.1016/j.cell.2006.12.023) Copyright © 2007 Elsevier Inc. Terms and Conditions