In Vino Veritas: A Tale of Two Sirt1s?

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Presentation transcript:

In Vino Veritas: A Tale of Two Sirt1s? Seung-Hoi Koo, Marc Montminy Cell Volume 127, Issue 6, Pages 1091-1093 (December 2006) DOI: 10.1016/j.cell.2006.11.034 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Resveratrol Stimulates the Sirt1-PGC-1α Pathway Resveratrol improves insulin sensitivity in mice by stimulating mitochondrial function via the Sirt1-PGC-1α pathway. Under basal conditions PGC-1α is heavily acetylated and inactivated by GCN5. Elevations in cellular NAD+ during fasting and in response to exercise trigger the Sirt1-mediated deacetylation of PGC-1α. Deacetylated PGC-1α stimulates genes for oxidative phosphorylation in part by functioning as a coactivator for nuclear respiratory factor-1 (NRF-1). Resveratrol increases Sirt1 activation under high-fat diet conditions by increasing the affinity of Sirt1 for NAD+ and for acetylated PGC-1α. Cell 2006 127, 1091-1093DOI: (10.1016/j.cell.2006.11.034) Copyright © 2006 Elsevier Inc. Terms and Conditions