A-01 TITLE LINE 1 arial font 8; all caps; bold TITLE LINE 2 Arial, Font size 8. 3 Lines for list of authors. List as First Name Last Name, First Name Last Name, etc. Department of __________, Baylor College of Medicine, Houston, TX (NOT the whole address) Arial, Font size 8. Abstract must fit in the allotted space.

A-01 NICOTINE DEPENDENCE, DEPRESSION VULNERABILITY AND THE REACTIVITY TO NEGATIVE STIMULI IN SMOKERS Yong Cui1, Jason D. Robinson2, Francesco Versace2, Cho Y. Lam2, Jennifer A. Minnix2, John A. Dani1, David W. Wetter3, Victoria L. Brown2 1Department of Neuroscience, Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, 2Department of Behavioral Science, Unit 1330, and 3Department of Health Disparities Research, Unit 1440, The University of Texas MD Anderson Cancer Center, Houston, TX. Nicotine dependence and depression is often comorbid. However, evidence from a psychophysiological perspective of how smokers of varied nicotine dependence severity and depression vulnerability may respond to negative cues differently is still lacking. To address this question experimentally, we presented smokers with pictures depicting positive, neutral and negative events, and examples of negative pictures included traffic accidents, mutilations and weapon attack. During the presentation of these categories of pictures, we measured smokers’ corrugator EMG activity to these visual stimuli, an indicator of response to negative stimuli. We found that although the nicotine dependence severity indexed by Fagerström Test for Nicotine Dependence score and depression vulnerability indexed by Depression Proneness Inventory score was largely uncorrelated, both dependence severity and depression vulnerability were positively correlated with the corrugator EMG activity to negative pictures. Importantly, the correlation between the corrugator EMG activity and depression vulnerability was only observed in more but not less dependent smokers. These findings suggest that besides nicotine dependence severity, smoking cessation invention practice should also pay attention to smokers’ depression vulnerability as both factors may influence quitters’ response to negative experimental cues, which has been associated with treatment failure (e.g., relapse).