Regine Gaetje, M. D. , Uwe Holtrich, Ph. D. , Thomas Karn, Ph. D

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Presentation transcript:

Characterization of WNT7A expression in human endometrium and endometriotic lesions Regine Gaetje, M.D., Uwe Holtrich, Ph.D., Thomas Karn, Ph.D., Eva Cikrit, Knut Engels, M.D., Achim Rody, M.D., Manfred Kaufmann, M.D. Fertility and Sterility Volume 88, Issue 6, Pages 1534-1540 (December 2007) DOI: 10.1016/j.fertnstert.2007.01.128 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Analysis of WNT7A mRNA expression in human endometrium and endometriosis by quantitative real-time polymerase chain reaction (PCR). WNT7A mRNA expression in the different tissues as revealed by quantitative real-time PCR is presented as box plots of the Δct values normalized to GPDH. A statistically significant difference was found among the three tissue types (P=.003; Kruskal-Wallis test) and when endometriotic tissue was compared with endometrium samples (P=.001 for all endometrium samples and P=.015 for endometrium from endometriosis patients, respectively; Mann-Whitney test). The difference between endometrium samples from patients with and without endometriosis was not statistically significant (P=.56; Mann-Whitney test). Fertility and Sterility 2007 88, 1534-1540DOI: (10.1016/j.fertnstert.2007.01.128) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 2 WNT7A mRNA and protein expression in human endometrium and endometriosis. WNT7A mRNA and antigen expression were analyzed by (A–C) in situ hybridization and (D–F) immunofluorescence (red staining) of eutopic endometrium (A, B, D, E) and endometriosis tissue (C and F). Cytokeratin (green) was used for counterstaining of epithelial cells in D, E, and F. The luminal (→) and glandular epithelial cells (▸) as well as stroma cells (S) show positive staining. Fertility and Sterility 2007 88, 1534-1540DOI: (10.1016/j.fertnstert.2007.01.128) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions