Gliomas “Dope Up” for Growth

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Presentation transcript:

Gliomas “Dope Up” for Growth Brenton R. Paolella, Charles D. Stiles Cancer Cell Volume 29, Issue 6, Pages 778-780 (June 2016) DOI: 10.1016/j.ccell.2016.05.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Differential Response of Normal and Malignant Neural Stem Cells to Dopamine Receptor 4 Antagonists Suggests Therapeutic Opportunities for Glioma Small molecule inhibitors of dopamine receptor 4 (DRD4) function (L-741, 742, or PNU 96415E) disrupt autophagic flux and trigger apoptosis in glioma stem cells, but not in normal neural stem cells. See Dolma et al. (2016) in this issue of Cancer Cell. Cancer Cell 2016 29, 778-780DOI: (10.1016/j.ccell.2016.05.010) Copyright © 2016 Elsevier Inc. Terms and Conditions