Essential Evidence Plus, Start *Table 1 Define PICO Question; Prioritize keywords Preliminary search If using Then do this Clinical Choose Filter, Queries Narrow vs. Broad Limits MeSh Each term “to Terms search box with “AND”, then combine Apply Limits Related articles Are Secondary sources appropriate? Use PubMed: Search each concept separately See Table 1* Use Cochrane, Essential Evidence Plus, TRIP Database No Yes Repeat or refine search See Table 2 ** Questions answered? P Patient, Problem, Population I Intervention/Indicator C Comparison, control, complication O Outcome No **Table 2 Yes Advanced search: Repeat using same or different method If need to Then do this Limit use “AND” Remove terms Add more limits Expand Use “OR” Alternative words Truncations Related articles Interpret and apply Therapy, Etiology, Harm RCT> Cohort > Case Control > Case Series Prevention RCT > Case Control > Case Series Diagnosis Prospective, Blind, Comparison compared to Gold Standard Prognosis Cohort > Case Control > Case Series End © Rachel Boykan, 2010