Doubly Dangerous: Extranodal NK/T-Cell Lymphoma

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Doubly Dangerous: Extranodal NK/T-Cell Lymphoma Shih-Jyun Yang, MD, Chau Yee Ng, MD, Chih-Hsun Yang, MD, Pei-Hsuan Lu, MD The American Journal of Medicine Volume 130, Issue 6, Pages 669-672 (June 2017) DOI: 10.1016/j.amjmed.2017.02.003 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The clinical manifestations of the disease were evident. (A) The patient had symmetrical violaceous swelling on both cheeks. Deep-seated induration occurred on palpation. (B) Faint violaceous patches could be seen on her neck, upper chest, and on both arms. (C) An ulcer measuring 1.3 × 1.3 cm and covered with necrotic tissue was located on the patient's left tonsil. The American Journal of Medicine 2017 130, 669-672DOI: (10.1016/j.amjmed.2017.02.003) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Histopathological examination of a skin biopsy specimen was essential to the diagnosis. (A) Dense, lymphocytic infiltrates were deep in the subcutis (hematoxylin and eosin, 20×). (B) Basal cell vacuolation, marked dermal edema, and diffuse hemorrhage were seen in the superficial dermis (hematoxylin and eosin, 100×). (C) Adipocytes were rimmed by medium-sized, atypical lymphoid cells (hematoxylin and eosin, 400×). (D) Epstein-Barr encoding region or EBER in situ hybridization revealed the Epstein-Barr virus in atypical lymphoid cells (400×). The American Journal of Medicine 2017 130, 669-672DOI: (10.1016/j.amjmed.2017.02.003) Copyright © 2017 Elsevier Inc. Terms and Conditions