Anti-Tau Antibodies: Hitting the Target Todd E. Golde, Jada Lewis, Nikolaus R. McFarland  Neuron  Volume 80, Issue 2, Pages 254-256 (October 2013) DOI: 10.1016/j.neuron.2013.10.009 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Model of Tau Seeding and Effects of Immunotherapy Exogenous pathological tau, presumably released from neurons, “seeds” formation of tau aggregates in other neurons and induces an inflammatory response (activated microglia and astrocytes), thereby propagating neuropathology. Anti-tau antibodies probably bind to exogenous pathological tau (including fibrils) and prevent both “seeding” and non-cell-autonomous neuroimmune response. The degree to which anti-tau antibodies might also get into neurons and affect spread of tau pathology is not represented here but should be considered. Neuron 2013 80, 254-256DOI: (10.1016/j.neuron.2013.10.009) Copyright © 2013 Elsevier Inc. Terms and Conditions