Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss Jan Tack, Huynh Giao Ly, Florencia Carbone, Hanne Vanheel, Tim Vanuytsel,

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Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss Jan Tack, Huynh Giao Ly, Florencia Carbone, Hanne Vanheel, Tim Vanuytsel, Lieselot Holvoet, Guy Boeckxstaens, Philip Caenepeel, Joris Arts, Lukas Van Oudenhove Clinical Gastroenterology and Hepatology Volume 14, Issue 3, Pages 385-392.e4 (March 2016) DOI: 10.1016/j.cgh.2015.09.043 Copyright © 2016 Terms and Conditions

Figure 1 (A) Change in DSS score after 8 weeks of mirtazapine or placebo. (B) Individual line plots of changes in severity ratings of early satiety. *P < .05 compared with baseline within the mirtazapine arm. †P < .05 change from baseline between treatments. Clinical Gastroenterology and Hepatology 2016 14, 385-392.e4DOI: (10.1016/j.cgh.2015.09.043) Copyright © 2016 Terms and Conditions

Figure 2 (A) Change in body weight after 4 and 8 weeks of treatment with placebo or mirtazapine. (B) Change in meal volume tolerance during nutrient challenge test after 8 weeks of treatment with placebo or mirtazapine. *P < .05 compared with baseline within the mirtazapine arm. †P < .05 change from baseline between treatments. Clinical Gastroenterology and Hepatology 2016 14, 385-392.e4DOI: (10.1016/j.cgh.2015.09.043) Copyright © 2016 Terms and Conditions

Supplementary Figure 1 Schematic study outline. PHQ, patient health questionnaire. Clinical Gastroenterology and Hepatology 2016 14, 385-392.e4DOI: (10.1016/j.cgh.2015.09.043) Copyright © 2016 Terms and Conditions

Supplementary Figure 2 Influence of 8 weeks of placebo treatment on daily diary ratings of dyspeptic symptoms. (A) Early satiation, (B) postprandial fullness, (C) epigastric pain, (D) nausea, and (E) belching. *P < .05 compared with baseline within the mirtazapine arm. #P < .05 compared with baseline within the placebo arm. Clinical Gastroenterology and Hepatology 2016 14, 385-392.e4DOI: (10.1016/j.cgh.2015.09.043) Copyright © 2016 Terms and Conditions