Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort Julia Dratva, MD, MPH,

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Presentation transcript:

Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort Julia Dratva, MD, MPH, Christian Schindler, PhD, Ivan Curjuric, MD, Daiana Stolz, MD, MPH, Ferenc Macsali, MD, Francisco Real Gomez, MD, PhD, Elisabeth Zemp, MD, MPH Journal of Allergy and Clinical Immunology Volume 125, Issue 4, Pages 823-829 (April 2010) DOI: 10.1016/j.jaci.2009.12.938 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study sample: flow chart. FVC, Forced vital capacity; HRT, hormone replacement therapy. Journal of Allergy and Clinical Immunology 2010 125, 823-829DOI: (10.1016/j.jaci.2009.12.938) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Distribution of day of methacholine challenge in relation to first day of menstruation: menstrual cycle day on day of methacholine challenge test; 0 corresponds to the first day of menstruation. Journal of Allergy and Clinical Immunology 2010 125, 823-829DOI: (10.1016/j.jaci.2009.12.938) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Cyclic pattern of hyperreactivity across the menstrual cycle in women with regular cycles of >24 or <32 days (N = 366). Adjusted for age, BMI, smoking status, asthma, baseline FEV1, age at menarche, and study center (random effect); 0 and 1 correspond to the first day of menstruation, 0.5 to midcycle. Green dotted lines, CI; black dotted line, estimated probability of hyperreactivity. Journal of Allergy and Clinical Immunology 2010 125, 823-829DOI: (10.1016/j.jaci.2009.12.938) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions