Vamsidhar Velcheti, MD, David L. Rimm, MD, PhD, Kurt A

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Sarcomatoid Lung Carcinomas Show High Levels of Programmed Death Ligand-1 (PD- L1) Vamsidhar Velcheti, MD, David L. Rimm, MD, PhD, Kurt A. Schalper, MD, PhD Journal of Thoracic Oncology Volume 8, Issue 6, Pages 803-805 (June 2013) DOI: 10.1097/JTO.0b013e318292be18 Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Sarcomatoid lung carcinomas show increased PD-L1 protein levels. A, Representative microphotographs showing PD-L1 and CK positivity in giant cell lung carcinoma. Left panels include hematoxylin & eosin-stained preparations at 200× (upper) and 400× magnification (lower panel). Giant cell carcinomas show characteristic lack of typical epithelial cohesiveness, a prominent mixed inflammatory infiltrate and bizarre giant tumor cells with single or multiple nuclei and focal leukocyte engulfment (emperipolesis, arrows). The right panels show fluorescence captions of PD-L1 (upper, red channel) and CK (lower, green channel) positivity of the same sample. Nuclei were stained with 4′, 6-diamidino-2-phenylindole (blue channel). B, Representative fluorescence microphotographs showing PD-L1 staining in formalin-fixed paraffin-embedded term human placenta (upper panels) and Mel624 transfectants (lower panels). PD-L1 positivity in placental samples was restricted to the trophoblastic cells (CK positive compartment;right panel) and absent in the stromal areas (vimentin positive compartment; Vim, left panel). Bar = 100 µm. In the cell lines, PD-L1 signal was evident with a perinuclear or membranous pattern only in PD-L1-transfected Mel624 cells (bottom right panel) but not in parental cells (bottom left panel). Bar = 50 µm. C, Graph showing mean ± standard error mean PD-L1 AQUA scores in conventional NSCLC (left bar) and in Sarcomatous carcinomas (right bar). AQUA scores are expressed as arbitrary units (AU). Cases were measured in the same preparations. The number of cases in each group is indicated within each bar. **p < 0.01. AQUA; automated quantitative fluorescence analysis; PD-L1, programmed death ligand-1; CK, cytokeratine; NSCLC, non–small-cell lung cancer. Journal of Thoracic Oncology 2013 8, 803-805DOI: (10.1097/JTO.0b013e318292be18) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions