Krasimira M. Mikhova, BSE, Creighton W

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Effect of cytokine hemoadsorption on brain death–induced ventricular dysfunction in a porcine model Krasimira M. Mikhova, BSE, Creighton W. Don, MD, PhD, Michael Laflamme, MD, PhD, John A. Kellum, MD, Michael S. Mulligan, MD, Edward D. Verrier, MD, David G. Rabkin, MD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 1, Pages 215-224 (January 2013) DOI: 10.1016/j.jtcvs.2012.08.002 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Schematic of experimental design. Dashed vertical line indicates initiation of cytokine hemoadsorption (HA) in the brain death + HA group. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 215-224DOI: (10.1016/j.jtcvs.2012.08.002) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Effect of cytokine hemoadsorption (HA) on tumor necrosis factor (TNF) expression (A) and interleukin (IL)-6 expression (B). Brackets indicate standard errors of the mean. Dashed vertical line indicates initiation of cytokine HA in the brain death + HA group. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 215-224DOI: (10.1016/j.jtcvs.2012.08.002) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Effect of cytokine hemoadsorption (HA) on brain death–induced left ventricular (LV) systolic dysfunction (A) and LV diastolic dysfunction (B). Brackets indicate standard errors of the mean. Dashed vertical line indicates initiation of cytokine HA in the brain death + HA group. PRSW, Preload recruitable stroke work. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 215-224DOI: (10.1016/j.jtcvs.2012.08.002) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Correlation of cytokine concentration with indices of ventricular function. The load-independent index of contractility preload recruitable stroke work (PRSW) is correlated with tumor necrosis factor [TNF] (A) and log interleukin [IL-6 ] (B). The diastolic relaxation constant tau is correlated with [TNF] (C) and log [IL-6] (D). In all cases, the solid line indicates the linear regression and the dashed lines represent 95% confidence intervals. The equation for the linear regression, the coefficient of determination, the F statistic, and the P value for the slope of the linear regression are reported for each analysis. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 215-224DOI: (10.1016/j.jtcvs.2012.08.002) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions