Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI.

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Presentation transcript:

Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3T R.I. Bolbos, Ph.D., Jin Zuo, Ph.D., Suchandrima Banerjee, B.E., Thomas M. Link, M.D., C. Benjamin Ma, M.D., Xiaojuan Li, Ph.D., Sharmila Majumdar, Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 10, Pages 1150-1159 (October 2008) DOI: 10.1016/j.joca.2008.02.018 Copyright © 2008 Terms and Conditions

Fig. 1 Trabecular bone structure post-processing: bone and marrow ROI were outlined for the femur (A), lateral and medial condyles (B), tibia (C) and LT/MT (D); the tibial grid was derived from the epicondylar distance (unit [mm]=epicondylar distance×100/9). Osteoarthritis and Cartilage 2008 16, 1150-1159DOI: (10.1016/j.joca.2008.02.018) Copyright © 2008 Terms and Conditions

Fig. 2 A graphical representation of the segmented trabecular bone regions. The femur, tibia, LFC, MFC, LT, and MT are shown; the ROIs were defined similarly with a previous described method2. Osteoarthritis and Cartilage 2008 16, 1150-1159DOI: (10.1016/j.joca.2008.02.018) Copyright © 2008 Terms and Conditions

Fig. 3 Representative T1ρ and T2 maps for a control subject (A, C) and for an OA patient (B, D). Osteoarthritis and Cartilage 2008 16, 1150-1159DOI: (10.1016/j.joca.2008.02.018) Copyright © 2008 Terms and Conditions

Fig. 4 Trabecular bone structure data: apparent measures of trabecular bone fraction (BV/TV), trabecular number (Tb.N), trabecular separation (Tb.Sp), and trabecular thickness (Tb.Th) were computed in OA patients compared with controls, using the ANOVA F-test; *P<0.05. Osteoarthritis and Cartilage 2008 16, 1150-1159DOI: (10.1016/j.joca.2008.02.018) Copyright © 2008 Terms and Conditions

Fig. 5 Articular cartilage data: T1ρ and T2 relaxation times as well as thickness and normalized volume were computed in OA patients compared with controls, using the ANOVA F-test; to account for the variation in joint size, the calculated volume was normalized to the epicondylar distance of each respective subject; the epicondylar distance was used to standardize the volume due to its invariance to osteoarthritic changes; *P<0.05. Osteoarthritis and Cartilage 2008 16, 1150-1159DOI: (10.1016/j.joca.2008.02.018) Copyright © 2008 Terms and Conditions