Depletion of T cells, in particular CD8+ T cells, significantly abrogates HEV neogenesis in tumors. Depletion of T cells, in particular CD8+ T cells, significantly.

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Depletion of T cells, in particular CD8+ T cells, significantly abrogates HEV neogenesis in tumors. Depletion of T cells, in particular CD8+ T cells, significantly abrogates HEV neogenesis in tumors. A, Tumor growth rates (k, per day) for Treg− HEVlo (n = 15), Treg− HEVhi (n = 15), and Treg− CD4−/CD8− (n = 16) Foxp3DTR animals. Statistical significance was determined by one-way ANOVA with Tukey test to compare pairs of means (**, P ≤ 0.01; ****, P ≤ 0.0001). B–E, Representative images of HEVs (PNAd+; brown) in tumors of (B) Treg−, (C) Treg− CD4−/CD8−, (D) Treg− CD4−, and (E) Treg− CD8− Foxp3DTR mice. Counterstain: hematoxylin. F, Total HEV area of Treg− CD4−/CD8− (n = 16), Treg− CD4− (n = 11), and Treg− CD8− (n = 8) animals compared with Treg− controls (n = 19). Data are presented as individual data points (individual mice) plus median. Statistical significance was determined by Mann–Whitney t tests; P values are shown for each group compared with Treg− controls. Emily J. Colbeck et al. Cancer Immunol Res 2017;5:1005-1015 ©2017 by American Association for Cancer Research