Volume 54, Issue 2, Pages (August 1998)

Slides:

Advertisements

Similar presentations

Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein-leaking dialyzers Francesco Galli, Serena Benedetti, Ardesio Floridi,

Advertisements

Date of download: 7/1/2016 Copyright © The American College of Cardiology. All rights reserved. From: A Randomized Controlled Trial to Prevent Post-Operative.

AHMED K. SALAMA AND OMRAN A. OMRAN Medical Laboratories Dept., Faculty of Science, Majmaah University, Kingdom of Saudi Arabia, 1434 H This report is based.

Volume 63, Issue 4, Pages (April 2003)

Pro-apoptotic low-density lipoprotein subfractions in type II diabetes

Volume 55, Issue 4, Pages (April 1999)

Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water Kuo-Chin Huang, Chih-Ching Yang, Kun-Tai.

Mingyu Liang, Carla R. Ramsey, Franklyn G. Knox Kidney International

Pro-apoptotic low-density lipoprotein subfractions in type II diabetes

Volume 55, Issue 4, Pages (April 1999)

Roles of antioxidant enzymes in corpus luteum rescue from reactive oxygen species- induced oxidative stress Kaïs H. Al-Gubory, Catherine Garrel, Patrice.

Volume 115, Issue 6, Pages (December 1998)

Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells Hi Bahl.

Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide.

Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury Zhe Wang, Sudhir.

Red cells from glutathione peroxidase-1–deficient mice have nearly normal defenses against exogenous peroxides by Robert M. Johnson, Gerard Goyette, Yaddanapudi.

Volume 67, Issue 2, Pages (February 2005)

Volume 64, Issue 2, Pages (August 2003)

Hyperketonemia (ketosis), oxidative stress and type 1 diabetes

Human mesangial cells express inducible macrophage scavenger receptor

Sorbitol transport in rat renal inner medullary interstitial cells

Volume 63, Issue 1, Pages (January 2003)

Volume 55, Issue 2, Pages (February 1999)

Volume 66, Issue 6, Pages (December 2004)

Volume 62, Issue 2, Pages (August 2002)

Volume 96, Issue 9, Pages (May 2009)

Effect of alternative peritoneal dialysis solutions on cell viability, apoptosis/necrosis and cytokine expression in human monocytes1 Joerg Plum, Mohammad.

Volume 63, Issue 2, Pages (February 2003)

Volume 59, Issue 5, Pages (May 2001)

Volume 65, Issue 4, Pages (April 2004)

Anna A. Shvedova, Choudari Kommineni, Bettricia A

Inhibition of glomerular cell apoptosis by heparin

Volume 59, Issue 5, Pages (May 2001)

Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water Kuo-Chin Huang, Chih-Ching Yang, Kun-Tai.

Volume 56, Issue 6, Pages (December 1999)

C.-C. Yang, S.-P. Hsu, M.-S. Wu, S.-M. Hsu, C.-T. Chien

Volume 67, Issue 3, Pages (March 2005)

Ahmad Nadeem, MSca, Sunil K

N-terminal fragments of the proatrial natriuretic peptide in patients before and after hemodialysis treatment Martina Franz, Wolfgang Woloszczuk, Walter.

Volume 64, Issue 2, Pages (August 2003)

Volume 64, Issue 1, Pages (July 2003)

Akito Maeshima, Yoshihisa Nojima, Itaru Kojima Kidney International

Protective effect of vitamin C on 8-hydroxy-2′-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients Der-Cherng Tarng,

Volume 54, Issue 3, Pages (September 1998)

Volume 68, Issue 2, Pages (August 2005)

Volume 55, Issue 4, Pages (April 1999)

Volume 57, Issue 2, Pages (October 2000)

Volume 8, Issue 3, Pages (June 2002)

Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells Peng-Fei.

Volume 67, Issue 1, Pages (January 2005)

Volume 62, Issue 2, Pages (August 2002)

Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells Fan Yi, Andrew Y. Zhang, Jennifer L.

Volume 70, Issue 4, Pages (August 2006)

Yoshihisa Ishikawa, Masanori Kitamura Kidney International

Volume 59, Issue 6, Pages (June 2001)

Wayel Jassem, Nigel D. Heaton Kidney International

Tumor necrosis factor-α and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells Udo K. Meßmer, Verena A. Briner, Josef.

Volume 62, Issue 4, Pages (October 2002)

Volume 60, Issue 4, Pages (October 2001)

Volume 62, Issue 4, Pages (October 2002)

Volume 79, Issue 12, Pages (June 2011)

Volume 68, Issue 1, Pages (July 2005)

Volume 72, Issue 4, Pages (August 2007)

Volume 61, Issue 3, Pages (March 2002)

Volume 56, Issue 2, Pages (August 1999)

Volume 54, Issue 4, Pages (October 1998)

Volume 58, Issue 2, Pages (August 2000)

Thiol Antioxidants Block the Activation of Antigen-Presenting Cells by Contact Sensitizers Stefanie Bruchhausen, Sabine Zahn, Elke Valk, Jürgen Knop,

Volume 65, Issue 6, Pages (June 2004)

Yasuo Kohjimoto, Lori Kennington, Cheryl R. Scheid, Thomas W. Honeyman

Presentation transcript:

Volume 54, Issue 2, Pages 580-589 (August 1998) Bioreactivity and biocompatibility of a vitamin E-modified multi-layer hemodialysis filter Francesco Galli, Simona Rovidati, Laura Chiarantini, Gianni Campus, Franco Canestrari, Umberto Buoncristiani Kidney International Volume 54, Issue 2, Pages 580-589 (August 1998) DOI: 10.1046/j.1523-1755.1998.00021.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Schematic structure of the surface modification in the CL-E filters. Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Effect of CL-S (dashed line) and CL-E (solid line) filters on lipoperoxidation and antioxidant consumption in a buffered suspension of lipoperoxides (LOOH) purified from rat brain homogenate. (A) In these experiments, malondialdehyde (MDA) formation was determined by thiobarbituric acid test. The LOOH suspension was incubated in the filters as described in the Methods section with (▪, •) or without (□, ○) 500 μm of reduced glutathione (GSH) and 100 μm ascorbic acid (AA). (B) In the case of the presence of these antioxidants their oxidation subproducts, namely oxidized glutathione (GSSG; ▪, •) and dehydroascorbic acid (DHA; □, ○), were measured. Data are the mean ± sd of five experiments performed in duplicate. Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Luminol-dependent chemiluminescence (LDC) production over time after in vitro phorbol 12-myristate 13-acetate (PMA) stimulation of leukocytes exposed for 15 and 30minutes to CL-S (▩) and CL-E (▨) filters. One × 104 leukocytes/ml were suspended in PBS plus glucose and albumin (both at a final concentration of 0.1% wt/vol) at a final volume of 2ml in the presence of 10mm luminol and 15nm PMA. Viability at 15minutes and at 30minutes was 89% and 91%, respectively. The data are expressed as mean ± sd of five measurements, and represent the integration area of the photon emission curves recorded as described in the Methods section. *P < 0.001 CL-S vs. CL-E. Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Effect of treatment with CL-E and CL-S on apoptosis of mononuclear leukocytes and its correlation with the plasma and red blood cell (RBC) vitamin E levels. Apoptosis was determined by fluorescence microscopy of nuclear morphology and expressed as the percentage of cells bearing fragmented nuclei among the total cell population, counting at least 300 cells in at least 5 randomly selected fields. The determinations were carried out after 24hours of colture as described in the Methods section. The mean value of apoptotic cells in the controls was 6.5 ± 2.3%. Data represent the mean ± sd calculated from two cell specimens per subject counted twice by two different operators. Symbols are: (▴) RBC vitamin E; (•) plasma vitamin E; (▪) apoptotic cells.*P < 0.05 and #P < 0.01. time 0 versus 1 and 3months. Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Interaction between hydrophilic antioxidants and vitamin E in the scavenging of lipoperoxides in the cell membrane and plasma lipids. Abbreviations are: L, polyunsaturated fatty acid; Vit. E (·), tocopherol and tocopheryl radicals; Vit. C (·), ascorbic acid and dehydroascorbic radical; GSH and GSSG, reduced and oxidized glutathione; NADP+ and NADPH, nicotinamide adenine dinucleotide phosphate, oxidized and reduced forms; HMPS, hexose monophosphate shunt. (1) Hexose monophosphate shunt activity (glucose-dependent); (2) glutathione reductase activity; (3) glutathione peroxidase activity. Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 580-589DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 580-589DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 580-589DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 580-589DOI: (10.1046/j.1523-1755.1998.00021.x) Copyright © 1998 International Society of Nephrology Terms and Conditions