Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

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Presentation transcript:

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells Ben S. Lam, Gregor B. Adams Cell Stem Cell Volume 8, Issue 4, Pages 354-356 (April 2011) DOI: 10.1016/j.stem.2011.03.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Selective Targeting of Cancer Stem Cells by Echinomycin Under normoxic conditions, HIF1α is active in cancer stem cells (CSCs), but not in hematopoietic stem cells (HSCs). Through selective targeting of HIF1α, echinomycin efficiently eliminates CSCs while sparing the normal HSCs. As a result, CSC maintenance is disrupted, and there is no tumor formation when these cells are transplanted into immunodeficient mouse hosts. Cell Stem Cell 2011 8, 354-356DOI: (10.1016/j.stem.2011.03.006) Copyright © 2011 Elsevier Inc. Terms and Conditions