Mortality Rates of Human Metapneumovirus and Respiratory Syncytial Virus Lower Respiratory Tract Infections in Hematopoietic Cell Transplantation Recipients

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Presentation transcript:

Mortality Rates of Human Metapneumovirus and Respiratory Syncytial Virus Lower Respiratory Tract Infections in Hematopoietic Cell Transplantation Recipients Christian Renaud, Hu Xie, Sachiko Seo, Jane Kuypers, Anne Cent, Lawrence Corey, Wendy Leisenring, Michael Boeckh, Janet A. Englund Biology of Blood and Marrow Transplantation Volume 19, Issue 8, Pages 1220-1226 (August 2013) DOI: 10.1016/j.bbmt.2013.05.005 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) RT-PCR results on nasal washes (X) sampled within 11 days before or after the positive BAL. Negative nasal washes were found in five patients with HMPV LRTD, whereas all patients with RSV LRTD had at least one positive nasal wash. Negative nasal washes were found in patients with lower BAL viral load. (B) RT-PCR results on sera (X) sampled within 11 days before or after the positive BAL. One patient with HMPV LRTD had two positive sera (HMPV patient three), whereas two patients with RSV LRTD had positive sera (RSV patients two and seven). All three patients with positive sera had a high BAL viral load and died. Biology of Blood and Marrow Transplantation 2013 19, 1220-1226DOI: (10.1016/j.bbmt.2013.05.005) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Kaplan-Meier survival estimates for (A) RSV and HMPV LRTD and (B) RSV or HMPV LRTD according to steroid dose. (C) HMPV LRTD treated with ribavirin and untreated. Biology of Blood and Marrow Transplantation 2013 19, 1220-1226DOI: (10.1016/j.bbmt.2013.05.005) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions