Effect of milrinone on coronary artery bypass grafts

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Presentation transcript:

Effect of milrinone on coronary artery bypass grafts Guo-Wei He, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 114, Issue 2, Pages 302-304 (August 1997) DOI: 10.1016/S0022-5223(97)70171-5 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Mean concentration (–log M)-contraction (percentage of 100 mmol/L K+–induced contraction) curves for endothelin-1. Three rings obtained from each patient were allocated to each treatment. One ring was the control (●) without pretreatment of milrinone. For the other two rings, milrinone 7 μmol/L (○) or 70 (▴) μmol/L was added into the organ bath 10 minutes before the start of the endothelin-1 curve. Symbols represent data averaged from six rings (from six patients). Vertical error bars are 1 standard error of mean values. **p < 0.01, analysis of variance among the three groups and Scheffe's F test compared with the control at the maximal contraction. Mil, Milrinone. (From He and Yang. Inhibition of Vasoconstriction by Phosphodiesterase III Inhibitor Milrinone in Human Conduit Arteries Used as Coronary Bypass Grafts. J Cardiovasc Pharmacol 1996;28:208-14; published with permission of Lippincott-Raven Publishers, Philadelphia, Pa.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 302-304DOI: (10.1016/S0022-5223(97)70171-5) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig .2 Relaxation induced by milrinone 3 μmol/L (●, n = 5), nitroglycerin 10 nmol/L (○, n = 5), or a combination of the two (▴, n = 6) in the human internal thoracic artery precontracted by potassium chloride (K+, 25 mmol/L). Δ, EA+B, Theoretic overadditive curve (see reference 4). *p < 0.05 compared with nitroglycerin and theoretic curve. Vertical error bars are 1 standard error of mean values. Mil, Milrinone; GTN, nitroglycerin. (From He, Yang, Gately, et al. Potential Greater Than Additive Vasorelaxant Actions of Milrinone and Nitroglycerin on Human Conduit Arteries. Br J Clin Pharmacol 1996;41:101-7; published with permission of Blackwell Science Ltd., Oxford, United Kingdom.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 302-304DOI: (10.1016/S0022-5223(97)70171-5) Copyright © 1997 Mosby, Inc. Terms and Conditions