Jelena Kolic, James D. Johnson Cell Metabolism

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Volume 14, Issue 2, Pages (August 2011)

Does Reduced Creatine Synthesis Protect against Statin Myopathy?

Ghrelin—a new player in glucose homeostasis?

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Metabolism by Remote Control

Something Old, Something New, Something Borrowed …

Boosting Bacterial Metabolism to Combat Antibiotic Resistance

Does Hypothalamic Inflammation Cause Obesity?

Pancreatic β cells: Responding to the matrix

Serotonin and the Orchestration of Energy Balance

Volume 24, Issue 3, Pages (September 2016)

Fingered for a Fat Fate Cell Metabolism

A Clock Ticks in Pancreatic β Cells

Gal3 Links Inflammation and Insulin Resistance

The Liver as a Hub in Thermogenesis

Independent Control of Aging and Axon Regeneration

Insulin biosynthesis: The IREny of it all

Volume 26, Issue 1, Pages 6-7 (July 2017)

Treating Obesity? It's in the Bag!

Life Is Short, if Sweet Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Autophagy: A Sweet Process in Diabetes

Making Biological Sense of GWAS Data: Lessons from the FTO Locus

Autophagy: A Potential Link between Obesity and Insulin Resistance

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Volume 130, Issue 6, (September 2007)

Silencing Insulin Resistance through SIRT1

Volume 11, Issue 3, Pages (March 2010)

Sweet Relief: Reprogramming Gastric Endocrine Cells to Make Insulin

Volume 91, Issue 6, Pages (September 2016)

Do Cancer Cells Care If Their Host Is Hungry?

Exercise Controls Non-Coding RNAs

Treating obesity: Does antagonism of NPY fit the bill?

Volume 14, Issue 2, Pages (August 2011)

Anna B. Osipovich, Mark A. Magnuson Cell Stem Cell

Oxytocin: The Neuropeptide of Love Reveals Some of Its Secrets

Role reversal: Brain insulin and liver STAT3

Hap1 and GABA: Thinking about food intake

Removing the Bone Brake

Macrophage Metabolism Shapes Angiogenesis in Tumors

Stem Cells and Oxidants: Too Little of a Bad Thing

Should I Stay or Should I Go: A Clash of α-Cell Identity

Of Mice and Men: Not ExAKTly the Same?

Volume 134, Issue 6, (September 2008)

David Hubel and Torsten Wiesel

AMPK and p53 help cells through lean times

Estrogens and Obesity: Is It All in Our Heads?

Presentation transcript:

Specialized Hub Beta Cells Trade Maximal Insulin Production for Perfect Timing Jelena Kolic, James D. Johnson Cell Metabolism Volume 24, Issue 3, Pages 371-373 (September 2016) DOI: 10.1016/j.cmet.2016.08.022 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Hub Beta Cells Set the Pace for Synchronized Beta Cell Work Hub cells have more glucokinase (Gck) but less insulin, possibly due to the lower expression of the key transcription factors Pdx1 and Nkx6.1. Hubs serve to set the islet’s pace, likely in response to neuronal stimulation. Follower cells produce more insulin and are connected to each other via gap junctions. Rowing image courtesy of Wikimedia Commons. Cell Metabolism 2016 24, 371-373DOI: (10.1016/j.cmet.2016.08.022) Copyright © 2016 Elsevier Inc. Terms and Conditions