Lower Incidence of Esophagitis in the Elderly Undergoing Definitive Radiation Therapy for Lung Cancer Payal D. Soni, MD, Philip S. Boonstra, PhD, Matthew.

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Lower Incidence of Esophagitis in the Elderly Undergoing Definitive Radiation Therapy for Lung Cancer Payal D. Soni, MD, Philip S. Boonstra, PhD, Matthew J. Schipper, PhD, Latifa Bazzi, BA, Robert T. Dess, MD, Martha M. Matuszak, PhD, Feng-Ming Kong, MD, PhD, James A. Hayman, MD, MBA, Randall K. Ten Haken, PhD, Theodore S. Lawrence, MD, PhD, Gregory P. Kalemkerian, MD, Shruti Jolly, MD Journal of Thoracic Oncology Volume 12, Issue 3, Pages 539-546 (March 2017) DOI: 10.1016/j.jtho.2016.11.2227 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Descriptive summary of the incidence of esophagitis in the University of Michigan cohort. D2cc, minimum dose to the most exposed 2 cm3 of the esophagus. Journal of Thoracic Oncology 2017 12, 539-546DOI: (10.1016/j.jtho.2016.11.2227) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Descriptive summary of the incidence of pneumonitis in the University of Michigan cohort. V20Gy, volume of both lungs not involved with gross disease that received at least 20 Gy. Journal of Thoracic Oncology 2017 12, 539-546DOI: (10.1016/j.jtho.2016.11.2227) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Predicted risk (Pr) of grade 3 or higher esophagitis at seven different minimum doses to the most exposed 2 cm3 of the esophagus as a function of age for a hypothetical patient who is assumed to be a never-smoker with a Karnofsky performance status of 85 who is receiving concurrent chemotherapy. Journal of Thoracic Oncology 2017 12, 539-546DOI: (10.1016/j.jtho.2016.11.2227) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions