Localized involutional lipoatrophy with epidermal and dermal changes

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Localized involutional lipoatrophy with epidermal and dermal changes Ossama Abbas, MD, Salah Salman, MD, Abdul Ghani Kibbi, MD, Adele Chedraoui, MD, Samer Ghosn, MD  Journal of the American Academy of Dermatology  Volume 58, Issue 3, Pages 490-493 (March 2008) DOI: 10.1016/j.jaad.2007.06.030 Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Well-demarcated, noninflamed, hypopigmented depression on left thigh in case 1 (A) and on right arm in case 2 (B). Note lack of hair follicles in lesional compared with nonlesional skin. Journal of the American Academy of Dermatology 2008 58, 490-493DOI: (10.1016/j.jaad.2007.06.030) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, Histopathology (case 1) reveals, at low power, epidermal atrophy, significant pandermal fibrosis with compaction and homogenization of collagen bundles, entrapment of eccrine glands high in dermis, and adipose tissue changes. Note parallel array of compacted collagen bundles in papillary dermis. B, Close-up view of eccrine coils in upper dermis highlights loss of perieccrine fat pad and surrounding dermal fibrosis. (Hematoxylin-eosin stain; original magnification: ×100.) C, Subcutaneous tissue shows diminutive fat lobules composed of small adipocytes in hyalinized and highly vascularized stroma. (Hematoxylin-eosin stain; original magnification: ×100.) D, Fontana-Masson stain reveals decreased basal keratinocyte pigmentation. Note epidermal atrophy and lack of superficial perivascular inflammation. (Original magnification: ×40.) Journal of the American Academy of Dermatology 2008 58, 490-493DOI: (10.1016/j.jaad.2007.06.030) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions