Fig. 2. In vitro sealing properties of the MeTro sealant.

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Fig. 2. In vitro sealing properties of the MeTro sealant.

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Fig. 2. In vitro sealing properties of the MeTro sealant. In vitro sealing properties of the MeTro sealant. (A) Standard lap shear test to determine the shear strength of MeTro sealants (n ≥ 4) with different formulations and several commercially available sealants: Evicel (n = 5), Coseal (n = 3), and Progel (n = 4). (i) Schematic of the modified standard test method for shear test (ASTM F2255-05), (ii) representative strain-stress curves for lap shear tests, and (iii) average shear strength of MeTro sealants produced with varying MeTro concentrations and degree of methacryloyl substitution, and commercially available sealants including Evicel, Coseal, and Progel. (B) Standard burst pressure test to evaluate the burst pressure of the MeTro sealant (n ≥ 4) with different formulations [except 5% Metro (n = 2)] and several commercially available sealants: Evicel (n = 4), Coseal (n = 3), and Progel (n = 5). (i) Schematic of the modified standard test method for the burst pressure (ASTM F2392-04), (ii) representative strain-stress curves for burst pressure test, and (iii) average burst pressure of the MeTro sealants with variable MeTro concentrations and degree of methacryloyl substitution, and commercially available sealants. (C) Standard wound closure using porcine skin as the biological substrate to test the adhesion strength of the MeTro sealant (n ≥ 4) with different formulations and commercially available sealants: Evicel (n = 5), Coseal (n = 3), and Progel (n = 3). (i) Schematic of the modified standard test method for adhesion strength (ASTM F2458-05), (ii) representative strain-stress curves for wound closure test, and (iii) average adhesive strength of MeTro sealants produced with variable MeTro concentrations and degree of methacryloyl substitution, and their comparison with commercially available sealants. Data are means ± SD. P values were determined by one-way ANOVA followed by Tukey’s multiple comparisons test (*P < 0.05, **P < 0.01, ****P < 0.0001). Nasim Annabi et al., Sci Transl Med 2017;9:eaai7466 Published by AAAS