Improving Carboplatin Dosing Based on Estimated GFR

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Presentation transcript:

Improving Carboplatin Dosing Based on Estimated GFR Jan H. Beumer, Lesley A. Inker, Andrew S. Levey American Journal of Kidney Diseases Volume 71, Issue 2, Pages 163-165 (February 2018) DOI: 10.1053/j.ajkd.2017.10.005 Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Determinants of carboplatin exposure, toxicity, and response in an individual patient. Carboplatin dose is determined using the Calvert formula, which requires the clinician to determine the target area-under-the-concentration-versus-time profile (AUC) and glomerular filtration rate (GFR). The target AUC is determined by tumor type and patient characteristics. GFR can be determined using measured or estimated GFR. Blue shaded cells indicate quantities determined by equations; green shaded cells, quantities decided by clinicians; and purple shaded cells, true quantities and subsequent events. Abbreviation: BSA, body surface area. American Journal of Kidney Diseases 2018 71, 163-165DOI: (10.1053/j.ajkd.2017.10.005) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions