An RNA Nexus in Neurodegeneration

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Presentation transcript:

An RNA Nexus in Neurodegeneration Cell Volume 158, Issue 5, (August 2014) DOI: 10.1016/j.cell.2014.08.015 Copyright © 2014 Terms and Conditions

Toxicity in the Drosophila eye is caused by “protein-only” poly (Gly-Arg) repeats, but not by “RNA-only” GGGGCC repeats of equivalent length. Image courtesy of S. Grönke. Cell 2014 158, DOI: (10.1016/j.cell.2014.08.015) Copyright © 2014 Terms and Conditions

Poly (Gly-Pro) proteins are observed in neurons derived from fibroblasts with the C9ORF72 repeat expansion. Cell 2014 158, DOI: (10.1016/j.cell.2014.08.015) Copyright © 2014 Terms and Conditions