A Dual Binding Receptor for ER-phagy

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A Dual Binding Receptor for ER-phagy Noboru Mizushima Developmental Cell Volume 44, Issue 2, Pages 133-135 (January 2018) DOI: 10.1016/j.devcel.2018.01.001 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 ER-phagy Receptors ER-phagy receptors that have been identified are shown. Saccharomyces cerevisiae have Atg39 and Atg40, whereas mammals have FAM134B, SEC62, RTN3, and CCPG1. All of these contain at least one LC3-interacting region (LIR) or Atg8-interacting motif (AIM). Additionally, CCPG1 has two FIP200-interacting regions (FIRs), and Atg39 has one Atg11-binding region (11BR). The Atg11-binding region in Atg40 is not yet identified. TM, transmembrane domain; RHD, reticulon-homology domain. Figure created by Haruka Chino. Developmental Cell 2018 44, 133-135DOI: (10.1016/j.devcel.2018.01.001) Copyright © 2018 Elsevier Inc. Terms and Conditions