Dipin Gupta, MD, Valentino Piacentino, PhD, Mahender Macha, MD, Arun K

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Effect of older donor age on risk for mortality after heart transplantation Dipin Gupta, MD, Valentino Piacentino, PhD, Mahender Macha, MD, Arun K. Singhal, MD, PhD, John P. Gaughan, PhD, James B. McClurken, MD, Bruce I. Goldman, MD, Carol A. Fisher, BA, Dan Beltramo, RN, John Monacchio, RN, BSN, Howard J. Eisen, MD, Satoshi Furukawa, MD The Annals of Thoracic Surgery Volume 78, Issue 3, Pages 890-899 (September 2004) DOI: 10.1016/j.athoracsur.2004.02.016

Fig 1 Use of donor hearts at least 50 years of age between 1990–2001 at Temple University Hospital. The Annals of Thoracic Surgery 2004 78, 890-899DOI: (10.1016/j.athoracsur.2004.02.016)

Fig 2 Kaplan–Meier survival curves after orthotopic heart transplantation between 1990–2002. Division of group by donor age at least 50 years; log-rank test between groups, p < 0.0001. (C.I. = confidence interval.) The Annals of Thoracic Surgery 2004 78, 890-899DOI: (10.1016/j.athoracsur.2004.02.016)

Fig 3 Recipient cause of death. Fisher exact test, * p < 0.05 for malignancy and early graft failure. (TCAD = transplant coronary arteriopathic disease.) The Annals of Thoracic Surgery 2004 78, 890-899DOI: (10.1016/j.athoracsur.2004.02.016)

Fig 4 Univariate hazard ratios of recipient- and donor-related risk factors analyzed in total cohort (n = 667). (CMV = cytomegalovirus; CPR = cardiopulmonary resuscitation; HF = heart failure; IABP = intraaortic balloon pump; PRA-B = pretransplant panel reactive antibodies to B-cell lymphocytes; PRA-T = pretransplant panel reactive antibodies to T-cell lymphocytes; VAD = ventricular assist device.) The Annals of Thoracic Surgery 2004 78, 890-899DOI: (10.1016/j.athoracsur.2004.02.016)

Fig 5 (A) Plot of Martingale residuals of final Cox regression model versus donor age with locally weighted regression line. (B) Enlargement of smoothed regression line. (C) Results of different donor age cut-points on fit of final Cox regression model; smallest value indicates best fit. The Annals of Thoracic Surgery 2004 78, 890-899DOI: (10.1016/j.athoracsur.2004.02.016)

Fig 6 Kaplan–Meier survival curves after orthotopic heart transplantation between 1990–2002. Division of group by donor age at least 40 years; log-rank test between groups, p < 0.0001. (C.I. = confidence interval.) The Annals of Thoracic Surgery 2004 78, 890-899DOI: (10.1016/j.athoracsur.2004.02.016)