Going Forward with Retromer

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Going Forward with Retromer Ginny G. Farias, David C. Gershlick, Juan S. Bonifacino Developmental Cell Volume 29, Issue 1, Pages 3-4 (April 2014) DOI: 10.1016/j.devcel.2014.03.018 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 The Role of Retromer in Neurons Left: Simplified view of endosomal trafficking pathways throughout the cell. The classical retromer pathway can be seen from the endosome to the TGN, as well as the more recently described pathway from the endosome to the plasma membrane. Retromer tubules are shown in green. Center: Structure and domains of a neuron. Right: Model of dendritic receptor delivery to plasma membrane by retromer. β2ARs (blue) are delivered to and function at the shaft, whereas neurotransmitter receptors such as AMPA- or NMDA-type glutamate receptors (red) function at the spine. Retromer tubules are shown in green. Developmental Cell 2014 29, 3-4DOI: (10.1016/j.devcel.2014.03.018) Copyright © 2014 Elsevier Inc. Terms and Conditions