Evaluating the Contribution of the Cause of Kidney Disease to Prognosis in CKD: Results From the Study of Heart and Renal Protection (SHARP) Richard.

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Presentation transcript:

Evaluating the Contribution of the Cause of Kidney Disease to Prognosis in CKD: Results From the Study of Heart and Renal Protection (SHARP) Richard Haynes, MRCP(UK), Natalie Staplin, PhD, Jonathan Emberson, PhD, William G. Herrington, MD, MRCP(UK), Charles Tomson, DM, Lawrence Agodoa, MD, Vladimir Tesar, PhD, Adeera Levin, FRCPC, David Lewis, MRCP(UK), Christina Reith, FRCP, Colin Baigent, FRCP, Martin J. Landray, PhD, FRCP American Journal of Kidney Diseases Volume 64, Issue 1, Pages 40-48 (July 2014) DOI: 10.1053/j.ajkd.2013.12.013 Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Cumulative incidence curves for end-stage renal disease (ESRD) by cause of kidney disease. These cumulative incidence curves account for the competing risk of death. American Journal of Kidney Diseases 2014 64, 40-48DOI: (10.1053/j.ajkd.2013.12.013) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Cumulative incidence curves for death from any cause before progression to end-stage renal disease (ESRD), by cause of kidney disease. These cumulative incidence curves account for the competing risk of ESRD. American Journal of Kidney Diseases 2014 64, 40-48DOI: (10.1053/j.ajkd.2013.12.013) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Effect of adjustment for known risk factors on the association between cause of kidney disease and end-stage renal disease, estimated using Cox regression. ∗Additional adjustment for prior diabetes has very little effect on the relative risks observed, but because the interpretation of the relative risk for the diabetic nephropathy group after adjustment for diabetes is unclear, it is not adjusted for in these analyses. Abbreviations: BMI, body mass index; BP, blood pressure; CI, confidence interval; eGFR, estimated glomerular filtration rate. American Journal of Kidney Diseases 2014 64, 40-48DOI: (10.1053/j.ajkd.2013.12.013) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Effect of adjustment for known risk factors on the association between cause of kidney disease and death at any time, estimated using Cox regression. Abbreviations: BMI, body mass index; BP, blood pressure; CI, confidence interval; eGFR, estimated glomerular filtration rate. American Journal of Kidney Diseases 2014 64, 40-48DOI: (10.1053/j.ajkd.2013.12.013) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions