Figure 4 Cascade system activation on a biomaterial surface

Slides:

Advertisements

Similar presentations

Effector mechanisms of humoral immunity The Complement System (C’) Activation pathways Effector functions Regulation of complement activation.

Advertisements

Complement Terry Kotrla, MS, MT(ASCP)BB Fall 2007.

114/14/2015 Complement Hugh B. Fackrell & Maria Sawicki.

Elainne Kesuma ( ) Harvianto Siman Santosa ( )

Innate Defenses Complement The complement system is a biochemical cascade that helps clear pathogens from an organism It is part of the innate immune system.

Complement Synthesis and attachment of specific antibody to invading microorganisms does not directly lead to destruction. It is a "label" that.

Humoral Immunity and Complement Robert Beatty MCB150.

The Complement System Amy Lovett-Racke, PhD Associate Professor Department of Microbial Infection and Immunity Reading: The Immune System, 3 rd Edition,

Biophysical Immunology Laboratory Thomas Vorup-Jensen Institute for Medical Microbiology and Immunology University of Aarhus Denmark

Complement. Innate Immunity Defensive mechanisms include : 1) Innate immunity (Natural or Non specific) 2) Acquired immunity (Adaptive or Specific ) Cell-mediated.

THE COMPLEMENT SYSTEM. The complement system The complement system is a set of plasma proteins that act in a cascade to attack and kill extracellular.

IMMUNOLOGY By ZOHA and SAMIHA.

The Complement System A group of > 30 plasma proteins which comprise the primary soluble component of innate immunity. Rapidly activated in response to.

The complement system is a biochemical cascade that helps, or “complements”, the ability of antibodies to clear pathogens from an organism. It is part.

The Complement system. objectives Factors involved in the immune response The complement system General properties of complement Cascade activation complement.

Mannose Binding Lectin (MBL) Pathway

The Complement system The complement system is an alarm and a weapon against infection, especially bacterial infection. activated directly by bacteria.

Complement Ali Al Khader, MD Faculty of Medicine

Chapter 6 The Complement System

Nat. Rev. Nephrol. doi: /nrneph

B lymphocyte Clonal Selection Process Plasma Cells.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Complement & Complement Fixation

Figure 4 Expression of coagulation protease receptors in renal cells

Figure 4 Interactions between adipose, the microbiome and kidney

Figure 1 Mechanisms of differential complement activation and

Figure 1 Pathways of complement activation

Figure 2 Overview of the complement system

Complement functions اپسونیزاسیون و فاگوسیتوز تحریک پاسخ های التهابی

Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Nephrol. doi: /nrneph

Figure 2 Three distinct mechanisms of activation of

Coagulation and innate immune responses: can we view them separately?

Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Oestrogen receptor signalling pathways

Nat. Rev. Nephrol. doi: /nrneph

Figure 2 Initiation, amplification and propagation of coagulation

Figure 1 The coagulation system

Figure 2 Emerging models of antibody-mediated rejection (ABMR) and

Nat. Rev. Nephrol. doi: /nrneph

Figure 4 The molecular configuration of the CD20 molecule

Figure 3 Therapeutic intervention in the complement cascade

Figure 3 Potential mechanisms of PAR activation by thrombin and aPC

Nat. Rev. Nephrol. doi: /nrneph

Innate Immune Responses to Transplants

during the alloimmune response

Figure 3 Pathological activation of complement

Figure 3 Biologics that attenuate effector responses in the kidney

Nat. Rev. Nephrol. doi: /nrneph

The inflammatory response.

Nat. Rev. Nephrol. doi: /nrneph

Complement Ali Al Khader, MD Faculty of Medicine

Terry Kotrla, MS, MT(ASCP)BB

Figure 4 The complement drug development pipeline

Figure 1 Sequence of events in the development of autoimmune nephritis

William G. Couser, Richard J. Johnson Kidney International

Complement Complement proteins become activated when they encounter antigen Cascading enzyme reactions concentrate activated complement at infection site.

Figure 1 Mechanisms of action of immunotherapy modalities

Complement in acute infection

Pathways for bradykinin formation and inflammatory disease

Overview The complement system is part of the innate immune system (vs adaptive) It is named “complement system” because it was first identified as a heat-labile.

Lec.8 COMPLEMENT SYSTEM.

Figure 1 The role of macrophages in RA

HUS and atypical HUS by T. Sakari Jokiranta Blood

The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target? Hrishikesh S. Kulkarni, MD, MSCI, M. Kathryn.

How I treat disseminated intravascular coagulation

Schematic model of the role of complement activation, cell damage, and thrombosis in various severe diseases or conditions with major thrombotic problems.

Presentation transcript:

Figure 4 Cascade system activation on a biomaterial surface Figure 4 | Cascade system activation on a biomaterial surface. On contact with blood, the surface of a biomaterial is immediately covered with a layer of plasma proteins by passive adsorption. Recognition of the surface occurs via two different mechanisms. Negatively charged surfaces tend to bind factor XII (FXII), which induces activation of the contact system, and C1q and properdin, which initiate or modulate complement activation via the classical and alternative pathway, respectively. On hydrophilic surfaces, certain proteins bind in altered, surface-activated conformations. These proteins include FXII, which activates the contact system; C3 (Ref. 112), which in the form of C3(H2O) can activate the alternative pathway of complement; and non-antigen bound IgG, which activates the classical pathway of complement. Activation and amplification of the complement system generates anaphylatoxins that recruit and activate polymorphonuclear cells (PMNs) and monocytes, thereby inducing an inflammatory response, whereas activation of the coagulation system generates thrombin, which recruits platelets and catalyses fibrin formation. Substantial crosstalk between the activated components of the cascade systems leads to further amplification of inflammatory and pro-thrombotic processes. Ab, antibody; Bb, activated factor B; C5aR, C5a anaphylatoxin chemotactic receptor 1; FcγR, Fcγ receptor; HK, high molecular weight kininogen; PAR1/4, proteinase-activated receptor 1/4; P2Y1/12, P2Y purinoceptor 1/12. Ekdahl, K. N. et al. (2017) Cardiovascular disease in haemodialysis: role of the intravascular innate immune system Nat. Rev. Nephrol. doi:10.1038/nrneph.2017.17