Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis Luis Escribano, MD, PhD, Andrés Garcı́a-Montero,

Slides:

Advertisements

Similar presentations

Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms Iván Álvarez-Twose,

Advertisements

The presence of membrane-bound stem cell factor on highly immature nonmetachromatic mast cells in the peripheral blood of a patient with aggressive systemic.

Image 1 Detection of minimal residual disease (MRD) in consecutive bone marrow (BM) samples from a patient with relapse (A) and a patient still in remission.

Figure 2 Percentage of CD19+/CD34+ cells with decreased CD81 median fluorescence intensity (MFI;

Human group 2 innate lymphoid cells do not express the IL-5 receptor

Cristina Teodosio, MSc, Andrés C

Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect- induced anaphylaxis shows unique features versus other indolent SM

Homozygous N-terminal missense mutation in TRNT1 leads to progressive B-cell immunodeficiency in adulthood Glynis Frans, MPharm, Leen Moens, PhD, Heidi.

Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose Scott P. Commins, MD, PhD, Hayley R. James,

Expression of PD-L1 in mastocytosis

Immunologic defects in 22q11.2 deletion syndrome

Recruitment of myeloid and plasmacytoid dendritic cells in cervical mucosa during Chlamydia trachomatis infection T. Agrawal, V. Vats, P.K. Wallace,

Timely follow-up of a GATA2 deficiency patient allows successful treatment Sara Ciullini Mannurita, MSc, Marina Vignoli, PhD, Gloria Colarusso, MD, PhD,

Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease Kirandeep.

Is 9 more than 2 also in allergic airway inflammation?

Bjorn van Anrooij, MD, Joanne N. G. Oude Elberink, MD, PhD, Lambert F

Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease Kirandeep.

Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder Michael D. Keller, MD, Rahul Pandey, PhD, Dong Li,

A history of pollen mapping and surveillance: The relations between natural history and clinical allergy Gregg Mitman, PhD Journal of Allergy and Clinical.

Susceptibility to influenza virus infection of bronchial biopsies in asthma Ben Nicholas, PhD, Sarah Dudley, PhD, Kamran Tariq, MD, Peter Howarth, DM,

Eosinophil protein in airway macrophages: A novel biomarker of eosinophilic inflammation in patients with asthma Neeta S. Kulkarni, MD, Fay Hollins,

Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect- induced anaphylaxis shows unique features versus other indolent SM

Extracutaneous mastocytoma

Successful hematopoietic stem cell transplantation for myelofibrosis in an adult with warts-hypogammaglobulinemia-immunodeficiency-myelokathexis syndrome

Eosinophilia in systemic mastocytosis: Clinical and molecular correlates and prognostic significance Alexandra Böhm, MD, Manuela Födinger, MD, Friedrich.

KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA- associated chronic eosinophilic leukemia are distinct entities Irina Maric,

TACI mutation with invasive polyclonal CD8+ T-cell lymphoproliferation in a patient with common variable immunodeficiency Lucinda J. Berglund, MBBS,

The National Biome Initiative: An allergy perspective

Floor Weerkamp, MSc, Edwin F. E. de Haas, BSc, Brigitta A. E

Mast cell activation syndrome: Proposed diagnostic criteria

Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels Patrizia Bonadonna, MD, Omar.

A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis Melody C. Carter, MD, Avanti Desai,

Expression of programmed cell death ligand-1 in mastocytosis correlates with disease severity Anja Rabenhorst, PhD, Silke Leja, MTA, Juliana Schwaab,

Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity Colin de Haar, PhD, Mirjam Kool, BSc, Ine.

Impact of immunotherapy on blood dendritic cells in patients with Hymenoptera venom allergy Katharina Dreschler, Kai Bratke, PhD, Sebastian Petermann,

The role of the mast cell in the pathophysiology of asthma

Human CD20+CD43+CD27+CD5− B cells generate antibodies to capsular polysaccharides of Streptococcus pneumoniae Bert Verbinnen, PhD, Kris Covens, PhD,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms Iván Álvarez-Twose,

What is an “eosinophilic phenotype” of asthma?

High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient Theoharis C. Theoharides,

Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis Melody C. Carter, MD, Sarah.

Serum levels of bone cytokines are increased in indolent systemic mastocytosis associated with osteopenia or osteoporosis Anja Rabenhorst, PhD, Bastian.

Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients Luis Escribano,

Autophagy: Nobel Prize 2016 and allergy and asthma research

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Luisa Lunardon, MD, Aimee S. Payne, MD, PhD

The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

One step forward, 2 steps back: The enigma of preschool wheeze

Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature Can N. Kocabas, MD, Akif.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Yui-Hsi Wang, PhD, Simon P. Hogan, PhD, Patricia C

Anaphylaxis Journal of Allergy and Clinical Immunology

Esophageal eosinophilia caused by milk proteins: From suspicion to evidence based on 2 case reports Soledad Terrados Cepeda, MD, Dario Antolin-Amerigo,

A flow cytometry–based diagnosis of eosinophilic esophagitis

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Diagnostic testing and interpretation of tests for autoimmunity

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Immunopathology of atopic dermatitis

Natural history of cow’s milk allergy

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Advances in mechanisms of allergic disease in 2016

Presentation transcript:

Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis Luis Escribano, MD, PhD, Andrés Garcı́a-Montero, PhD, Rosa Núñez-López, MD, Javier López-Jiménez, MD, PhD, Julia Almeida, MD, PhD, Aranzazu Prados, BSc, Alberto Orfao, MD, PhD Journal of Allergy and Clinical Immunology Volume 114, Issue 1, Pages 28-33 (July 2004) DOI: 10.1016/j.jaci.2004.02.042

Fig 1 A, May-Grünwald Giemsa-stained BM smear at diagnosis showing a massive infiltration by myeloid blast cells and an abnormal MC (arrow) with spindle shape, cytoplasmic prolongations, and oval nucleus. B, Toluidine blue staining revealed a dense compact aggregate of spindle-shaped MCs in a BM particle. Journal of Allergy and Clinical Immunology 2004 114, 28-33DOI: (10.1016/j.jaci.2004.02.042)

Fig 1 A, May-Grünwald Giemsa-stained BM smear at diagnosis showing a massive infiltration by myeloid blast cells and an abnormal MC (arrow) with spindle shape, cytoplasmic prolongations, and oval nucleus. B, Toluidine blue staining revealed a dense compact aggregate of spindle-shaped MCs in a BM particle. Journal of Allergy and Clinical Immunology 2004 114, 28-33DOI: (10.1016/j.jaci.2004.02.042)

Fig 2 Representative immunophenotypic characteristics of myeloid blast cells and MCs coexisting in the patient's BM. A-H, Myeloblasts. Note the presence of a small population of blast cells showing an immature (CD34+/CD45+) phenotype, suggesting commitment toward the MC lineage (CD117+++, tryptase-positive, FcεRI−/+, CD25−/+; blue dots) in contrast with a major population of non-MC CD34++ leukemic blast cells (red dots). I-L, CD117+++, selectively gated BM MCs from the same patient. In these panels, black dots correspond to CD25++, CD2+ aberrant mast cells and violet events to normal mast cells. APC, Allophycocyanine; ctryptase, cytoplasmic tryptase; FITC, fluorescein isothiocyanate; PE, phycoerythrin; PerCP, peridin chlorophyll protein. Journal of Allergy and Clinical Immunology 2004 114, 28-33DOI: (10.1016/j.jaci.2004.02.042)