The Future of Lung Transplantation Steven D. Nathan, MD, FCCP  CHEST  Volume 147, Issue 2, Pages 309-316 (February 2015) DOI: 10.1378/chest.14-1748 Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Data from the Scientific Registry of Transplant Recipients demonstrating growing trends in lung transplantation. A, Number of lung transplant recipients older than 65 y by year. B, Number of donors recovered in the United States by year. C, Number of lung transplant candidates added to the wait list in the United States by year vs the number of transplant performed. D, Number of older donors by year. CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Data from the Scientific Registry of Transplant Recipients demonstrating growing trends in lung transplantation. A, Number of lung transplant recipients older than 65 y by year. B, Number of donors recovered in the United States by year. C, Number of lung transplant candidates added to the wait list in the United States by year vs the number of transplant performed. D, Number of older donors by year. CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Data from the Scientific Registry of Transplant Recipients demonstrating growing trends in lung transplantation. A, Number of lung transplant recipients older than 65 y by year. B, Number of donors recovered in the United States by year. C, Number of lung transplant candidates added to the wait list in the United States by year vs the number of transplant performed. D, Number of older donors by year. CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Data from the Scientific Registry of Transplant Recipients demonstrating growing trends in lung transplantation. A, Number of lung transplant recipients older than 65 y by year. B, Number of donors recovered in the United States by year. C, Number of lung transplant candidates added to the wait list in the United States by year vs the number of transplant performed. D, Number of older donors by year. CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 2 Therapeutic advances in lung diseases for which transplantation might be an option. Included are available medications in the United States with years of approval, procedures, and anticipated approvals. Inh = inhaled; PAH = pulmonary arterial hypertension; SQ = subcutaneous; Trep = Treprostinil. CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 3 Photo depicting the early stages of ex vivo lung perfusion. After the acellular perfusate is pumped through the pulmonary artery (yellow) and out through the left atrium (green), the lungs are warmed to 32°C, the endotracheal tube is unclamped, and protective ventilation is begun. (Reprinted with permission from Perfusix USA, Inc.) CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 4 Schematic of CLAD with risk factors, potential predictors, and phenotypes. Abs = antibodies; BOS = bronchiolitis obliterans syndrome; CHF = congestive heart failure; CLAD = chronic lung allograft dysfunction; GERD = gastroesophageal reflux disease; HFpEF = heart failure with preserved ejection fraction; HLA = human leukocyte antigen. CHEST 2015 147, 309-316DOI: (10.1378/chest.14-1748) Copyright © 2015 The American College of Chest Physicians Terms and Conditions