Impact of high serum progesterone during the late follicular phase on IVF outcome Charlotte Sonigo, Géraldine Dray, Clémence Roche, Isabelle Cédrin-Durnerin,

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Presentation transcript:

Impact of high serum progesterone during the late follicular phase on IVF outcome Charlotte Sonigo, Géraldine Dray, Clémence Roche, Isabelle Cédrin-Durnerin, Jean-Noel Hugues Reproductive BioMedicine Online Volume 29, Issue 2, Pages 177-186 (August 2014) DOI: 10.1016/j.rbmo.2014.03.027 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 The different steps of steroidogenesis in humans. Reproductive BioMedicine Online 2014 29, 177-186DOI: (10.1016/j.rbmo.2014.03.027) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Steroidogenesis during follicular phase. (A) During the early follicular phase, LH acts exclusively on theca cells to stimulate 3βHSD type 2 to convert pregnenolone to progesterone and the CYP 17 enzymic complex to activate the conversion of progesterone or pregnenolone to 17 hydroxylated products. (B) During the late follicular phase, LH acts not only on theca cells but also on granulosa cells where LH receptors are strongly expressed in mature follicles. Reproductive BioMedicine Online 2014 29, 177-186DOI: (10.1016/j.rbmo.2014.03.027) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Reproductive BioMedicine Online 2014 29, 177-186DOI: (10. 1016/j. rbmo Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions