Clinical Nutrition Experimental

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Clinical Nutrition Experimental Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions Takuro Oyama, Nami Kakuta, Naoji Mita, Shinji Kawahito, Katsuya Tanaka, Yasuo M. Tsutsumi Clinical Nutrition Experimental Volume 19, Pages 1-11 (June 2018) DOI: 10.1016/j.yclnex.2018.04.002 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Study protocol. In the control group, participants fast after dinner and only ingest water on the day before the experiment. In the ONS (oral nutritional supplement) group, the participants fast after dinner on the day before the experiment and ingest 400 g of a jelly-type ONS before bed. Additionally, they ingest 400 g of ONS at 7:00 am on the morning of the experiment. At 9:00 am, blood sample is collected in both groups. Clinical Nutrition Experimental 2018 19, 1-11DOI: (10.1016/j.yclnex.2018.04.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 CONSORT flow chart showing the selection process for volunteers. After obtaining informed consent, the order in which the participants underwent the 2 experiments is decided randomly. ONS, oral nutritional supplement. Clinical Nutrition Experimental 2018 19, 1-11DOI: (10.1016/j.yclnex.2018.04.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Antral images. (A) at baseline and (B) immediately after ingestion of the jelly. IVC, inferior vena cava; SMV, superior mesenteric vein, L = liver. Arrows = gastric antrum. Clinical Nutrition Experimental 2018 19, 1-11DOI: (10.1016/j.yclnex.2018.04.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 Serum concentration of (A) free fatty acids, (B) total ketone bodies, (C) 3-MH/creatinine ratio, and (D) insulin. The boxes represent the 25th to 75th percentiles, and the horizontal lines within the boxes represent median values. The whiskers represent the lowest and highest values. FFA, free fatty acid; ONS, oral nutritional supplement; 3-MH/Cre. Clinical Nutrition Experimental 2018 19, 1-11DOI: (10.1016/j.yclnex.2018.04.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 5 Oxidative stress and antioxidant. (A) Serum d-ROMs levels. (B) Serum BAP levels. U.CARRd-ROMs, derivatives of reactive oxygen metabolites; BAP, biological antioxidant potential. Clinical Nutrition Experimental 2018 19, 1-11DOI: (10.1016/j.yclnex.2018.04.002) Copyright © 2018 The Authors Terms and Conditions