β-Agonists and metabolism

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β-Agonists and metabolism L.H. Philipson, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 110, Issue 6, Pages S313-S317 (December 2002) DOI: 10.1067/mai.2002.129702 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 The metabolic model of β-cell function. Under conditions of elevated glucose levels, an increase in the adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio induces closure of KATP channels. A depolarization results, activating L-type Ca2+ channels and leading to elevated [Ca2+]i. Activation of a K+ conductance, Kv, contributes to the oscillatory pattern of electrical activity and insulin secretion. cADPR , Cyclic ADP-ribose; *, transmembrane potential; ER , endoplasmic reticulum; GIRK , G-protein-gated inwardly rectifying K+ channels; GLUT , glucose transporter 2; IP 3R3 , inositol 1,4,5-triphosphate receptor 3; NSCC I CRAN, Ca2+-release activated nonselective cation current; RyR , ryanodine receptor; SERCA3 , sarco/endoplasmic reticulum Ca2+ adenosinetriphosphatase 3; Sk/IK/BK , small/intermediate/large K+ conductance channels; SU , sulfonylurea receptor-ATP-dependent K+ channel; VDCC , voltage-dependent Ca2+ channel; VDSC , voltage-dependent sodium channel. Journal of Allergy and Clinical Immunology 2002 110, S313-S317DOI: (10.1067/mai.2002.129702) Copyright © 2002 Mosby, Inc. Terms and Conditions