Fernando Martín-Belmonte, Wei Yu, Alejo E

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Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis Fernando Martín-Belmonte, Wei Yu, Alejo E. Rodríguez-Fraticelli, Andrew J. Ewald, Zena Werb, Miguel A. Alonso, Keith Mostov Current Biology Volume 18, Issue 13, (July 2008) DOI: 10.1016/j.cub.2008.06.055 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure S1. The Presence of Laminin in the ECM Reduces Apoptosis in Lumen Clearance (A and B) Effect of laminin on polarity, lumen formation, and apoptosis. MDCK cells were plated to form cysts in collagen (A) or LGF Matrigel (B). Cells were fixed at 1, 2, 3, 4, 5, 6, 7, and 10 days and stained to detect gp135 (red), ZO-1 or caspase-3 (green), and nuclei (lower panels). Images in the top row of (A) and bottom row of (B) are merged with DIC. Arrowheads indicate tight junctions in cells growing in Matrigel. Scale bars represent 5 μm. Current Biology 2008 18, DOI: (10.1016/j.cub.2008.06.055) Copyright © 2008 Elsevier Ltd Terms and Conditions