Volume 15, Issue 1, Pages (January 2008)

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Volume 15, Issue 1, Pages 43-50 (January 2008) Plant-Pathogenic Streptomyces Species Produce Nitric Oxide Synthase-Derived Nitric Oxide in Response to Host Signals Evan G. Johnson, Jed P. Sparks, Boris Dzikovski, Brian R. Crane, Donna M. Gibson, Rosemary Loria Chemistry & Biology Volume 15, Issue 1, Pages 43-50 (January 2008) DOI: 10.1016/j.chembiol.2007.11.014 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 Thaxtomin A Chemistry & Biology 2008 15, 43-50DOI: (10.1016/j.chembiol.2007.11.014) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 2 Evidence for NOS-Dependent NO Production (A) ESR spectra of 1 mM CPTIO from OBB-grown cultures of S. turgidiscabies strain Car8 after (1) 20 min and (2) 40 min, and (3) Car8Δnos after 40 min. (B) ESR spectra of Fe(DTCS)2 after a 30 min incubation in 3-day-old OBB cultures: (1) 1 μM DEANO, (2) S. turgidiscabies strain Car8, (3) uninoculated, (4) S. turgidiscabies strain Car8Δnos. (C) Chemiluminescence NO measurements from the headspace of S. turgidiscabies cultures grown on OBAC with or without the NOS inhibitor L-NAME. Data are presented as mean ± SD. Chemistry & Biology 2008 15, 43-50DOI: (10.1016/j.chembiol.2007.11.014) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 3 Comparison of NO Production to Thaxtomin A Accumulation Over Time (A) NO production rate in the culture headspace. (B) Total NO released to the culture headspace calculated by integrating the rate of release. (C) Accumulation of thaxtomin A in the culture medium in Car8 (solid diamonds) and Car8Δnos (open squares). Data are presented as mean ± SD. Chemistry & Biology 2008 15, 43-50DOI: (10.1016/j.chembiol.2007.11.014) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 4 Visualization of NO Production by S. turgidiscabies in Radish Seedlings with the NO-Reactive Dye, DAF-FM DA, by Using Confocal Fluorescence Microscopy (A–F) NO production by: wild-type strain Car8 colonizing (A) root tip, (B) root surface, (C) root hairs, and (D) root surface; and Car8Δnos colonizing (E) root surface and root hairs and (F) root tip; or the unstained controls of (G) Car8 and (H) Car8Δnos. Arrows designate hyphae with compartmentalized NO production. Scale bars are 50 μm. Chemistry & Biology 2008 15, 43-50DOI: (10.1016/j.chembiol.2007.11.014) Copyright © 2008 Elsevier Ltd Terms and Conditions