Learning the ABCs of Melanoma-Initiating Cells

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Learning the ABCs of Melanoma-Initiating Cells Susan E. Zabierowski, Meenhard Herlyn Cancer Cell Volume 13, Issue 3, Pages 185-187 (March 2008) DOI: 10.1016/j.ccr.2008.02.015 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 ABCB5 Expression in a Melanoma Stem Cell Hierarchy In the cancer stem cell hierarchy of melanoma, ABCB5+ melanoma-initiating cells give rise to more committed progenitor/transamplifying cells that may or may not express ABCB5, depending on the stage of differentiation, while terminally differentiated cells lack expression of ABCB5. Tumorigenic potential is lost as these cells proceed toward differentiation as well as chemoresistance due to the downmodulation of ABCB5, a doxorubicin efflux transporter. Cancer Cell 2008 13, 185-187DOI: (10.1016/j.ccr.2008.02.015) Copyright © 2008 Elsevier Inc. Terms and Conditions