Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition Mary Feeney, MSc, RD, George Du Toit, MBBCh, FRCPCH, Graham Roberts,

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Presentation transcript:

Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition Mary Feeney, MSc, RD, George Du Toit, MBBCh, FRCPCH, Graham Roberts, DM, Peter H. Sayre, MD, PhD, Kaitie Lawson, MS, Henry T. Bahnson, MPH, Michelle L. Sever, MSPH, PhD, Suzana Radulovic, MD, Marshall Plaut, MD, Gideon Lack, MBBCh, FRCPCH Susan Chan, Adam Fox, Mable Abraham, Muhsinah Adam, Lyn Clough, Louise Coverdale, Helen Fisher, Fiona Henley, Saadia Hussain, Victoria Johnston, Amy Nixon, Una O'Dwyer-Leeson, Aine Sheridan, Tammy Amarra, Kathryn Cockerell, Sarah Lacey, Gail Harland, Charlotte Stedman, Ruth Towell, Monica Basting, Catherine Clarke, Richard Cleaver, Gemma Deutsch, Erica Harris, Lori Nirenstein, Alicia Parr, Natalia Becares, Matthew Crossley, Natalia do Couto Francisco, Kerry Richards, Deeviya Patel, Ewa Pietraszewicz, Alick Stephens, Asha Sudra, Rianne Wester, Alastair Wilson, Celine Wu, Jenna Heath, Kathryn Hersee, Devi Patkunam, Michael Adamkiewicz, Adam Asare, Eduard Chani, Judith Evind, Kristina Harris, Noha Lim, Nariman Nasser, Audrey Plough, Jennifer Romaine, Michael Stahly, Joy Laurienzo Panza, Susan McCachren, Travis Mason, Valerie Nelson Mary Feeney, MSc, RD, George Du Toit, MBBCh, FRCPCH, Graham Roberts, DM, Peter H. Sayre, MD, PhD, Kaitie Lawson, MS, Henry T. Bahnson, MPH, Michelle L. Sever, MSPH, PhD, Suzana Radulovic, MD, Marshall Plaut, MD, Gideon Lack, MBBCh, FRCPCH Susan Chan, Adam Fox, Mable Abraham, Muhsinah Adam, Lyn Clough, Louise Coverdale, Helen Fisher, Fiona Henley, Saadia Hussain, Victoria Johnston, Amy Nixon, Una O'Dwyer-Leeson, Aine Sheridan, Tammy Amarra, Kathryn Cockerell, Sarah Lacey, Gail Harland, Charlotte Stedman, Ruth Towell, Monica Basting, Catherine Clarke, Richard Cleaver, Gemma Deutsch, Erica Harris, Lori Nirenstein, Alicia Parr, Natalia Becares, Matthew Crossley, Natalia do Couto Francisco, Kerry Richards, Deeviya Patel, Ewa Pietraszewicz, Alick Stephens, Asha Sudra, Rianne Wester, Alastair Wilson, Celine Wu, Jenna Heath, Kathryn Hersee, Devi Patkunam, Michael Adamkiewicz, Adam Asare, Eduard Chani, Judith Evind, Kristina Harris, Noha Lim, Nariman Nasser, Audrey Plough, Jennifer Romaine, Michael Stahly, Joy Laurienzo Panza, Susan McCachren, Travis Mason, Valerie Nelson Journal of Allergy and Clinical Immunology Volume 138, Issue 4, Pages 1108-1118 (October 2016) DOI: 10.1016/j.jaci.2016.04.016 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Journal of Allergy and Clinical Immunology 2016 138, 1108-1118DOI: (10 Journal of Allergy and Clinical Immunology 2016 138, 1108-1118DOI: (10.1016/j.jaci.2016.04.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Average peanut consumption over time (grams peanut protein per week). Peanut consumption summarized throughout the study from FFQs completed at baseline and between study visits. Median weekly consumption during the first 2 years of life (per-protocol adherence) has been previously published.1 Gray dots denote subjects randomized to the avoidance group. Green dots denote subjects randomized to the consumption group. Red circles denote participants who were peanut allergic at 60 months. Journal of Allergy and Clinical Immunology 2016 138, 1108-1118DOI: (10.1016/j.jaci.2016.04.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Growth and anthropometry in avoidance and consumption groups (ITT sample). Measures are weight, height, BMI, subscapular skinfold thickness, triceps skinfold thickness, and waist circumference. The bottom panel displays the difference in means (consumption – avoidance) and 95% CIs between the 2 randomized groups resulting from a model adjusted for randomization assignment and sex. ITT, Intent to treat. Journal of Allergy and Clinical Immunology 2016 138, 1108-1118DOI: (10.1016/j.jaci.2016.04.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Macronutrient intakes in avoidance and consumption groups as %TE (ITT sample) and differences in mean macronutrient intakes by quartile of peanut consumption. A, All data for both randomized groups. B, Difference in means (consumption – avoidance) and 95% CIs between the 2 randomized groups resulting from equivariance T tests. C, Difference in means (consumption – avoidance) and 95% CIs between the avoidance group and each quartile of peanut consumption resulting from equivariance T tests. ITT, Intent to treat. Journal of Allergy and Clinical Immunology 2016 138, 1108-1118DOI: (10.1016/j.jaci.2016.04.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions