Bahaaldin Alsoufi, MD, Cedric Manlhiot, BSc, William T

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Presentation transcript:

Low-weight infants are at increased mortality risk after palliative or corrective cardiac surgery Bahaaldin Alsoufi, MD, Cedric Manlhiot, BSc, William T. Mahle, MD, Brian Kogon, MD, William L. Border, MBChB, MPH, Angel Cuadrado, MD, Robert Vincent, MD, Brian W. McCrindle, MD, MPH, Kirk Kanter, MD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 6, Pages 2508-2514.e1 (December 2014) DOI: 10.1016/j.jtcvs.2014.07.047 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Association between unplanned cardiac reoperation and weight at surgery. B, Association between ECMO requirement and weight at surgery. C, Association between hospital mortality and weight at surgery. ECMO, Extracorporeal membrane oxygenation. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2508-2514.e1DOI: (10.1016/j.jtcvs.2014.07.047) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, Difference in postoperative ventilation, ICU and hospital stay between patients ≤2.5 kg (in red) and >2.5 kg (in gray). B, Association between postoperative ventilation duration and weight at surgery. C, Association between postoperative ICU stay and weight at surgery. D, Association between postoperative hospital stay and weight at surgery. ICU, Intensive care unit. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2508-2514.e1DOI: (10.1016/j.jtcvs.2014.07.047) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 A, Parametric hazard model for survival after surgery stratified by weight group (≤2.5 kg and >2.5 kg). B, Hazard function for mortality stratified by weight group (≤2.5 kg and >2.5 kg). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2508-2514.e1DOI: (10.1016/j.jtcvs.2014.07.047) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Hazard function for mortality after first surgery stratified by weight group (≤2.5 kg and >2.5 kg) and by single-ventricle versus biventricle anomaly. SV, Single ventricle; BV, biventricle. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2508-2514.e1DOI: (10.1016/j.jtcvs.2014.07.047) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Association between weight ≤2.5 kg (vs >2.5 kg) and postoperative survival among selected patient subgroups. The hazard ratio for mortality (with 95% confidence interval) for weight ≤2.5 kg is shown for each patient subgroup. Weight ≤2.5 kg was found to be associated with increased hazard of mortality in all subgroups. CPB, Cardiopulmonary bypass; HR, hazard ratio; CI, confidence interval; STAT, Society of Thoracic Surgeons—European Association for Cardio-Thoracic Surgery. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2508-2514.e1DOI: (10.1016/j.jtcvs.2014.07.047) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions