Crashpilot Underachieves due to Acetylation at the Nerve Terminal

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Presentation transcript:

Crashpilot Underachieves due to Acetylation at the Nerve Terminal Ruud F. Toonen, Matthijs Verhage Neuron Volume 72, Issue 5, Pages 679-681 (December 2011) DOI: 10.1016/j.neuron.2011.11.008 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Lysine Acetylation and Deacetylation in the Nucleus and at the Synaptic Terminal (A) Histone (green) acetylation (Ac) by histone acetylases (HATs) reduces DNA (blue) binding and promotes transcription. Deacetylation by histone deacetylases (HDACs) typically represses transcription. (B) ELP3-dependent acetylation of Bruchpilot (BRP, green) controls the structure of synaptic T bars and hinders tethering of synaptic vesicles (yellow). (C) Typical electron micrographs of T bar structure in control and elp3 mutants. Arrowheads indicate T bar lengths. Scale bar represents 200 nm. Images by K. Miśkiewicz were kindly provided by P. Verstreken. We thank Tina Marquardt-Kunit for the artwork. Neuron 2011 72, 679-681DOI: (10.1016/j.neuron.2011.11.008) Copyright © 2011 Elsevier Inc. Terms and Conditions